The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

7-11

Authors: S.V. Kalinichenko

The investigation of adhesive properties of toxin-forming strains of Corynebacteria after irradiation of electromagnetic waves of extremely high-frequency (EHF) range it was discovered the differentiated changes. It is proved that the treatment of test-cultures of toxin-forming strains of Corynebacteria by electromagnetic waves (42.2 GHz) contributed to the decrease microbes’ adhesive activity, whereas the influence of range (61.0 GHz) contributed to the stimulation of above-mentioned activity. The irradiation by electromagnetic waves with frequency 40.0 GHz, 58.0 GHz and 64.5 GHz did not reduce to the changes of observing adhesive properties of Corynebactiria. The dependency of effect of electromagnetic radiation from irradiation’s time of test-cultures is established. Evident effects are established only for bacteria irradiated during not less than 8 hours.

15-19

Authors: E.V. Sirenko

The ability of TG «Rosa» to damage immunological resistance in doses of 1/100 and 1/1000 LD50 was found in the experiment on the warm-blooded animals. It was revealed the occurring of hole-cell, the occurring of functional activity splenar – cells, timus and the increase of plasma – cells reaction in the splenar and lymphatic nodules of animals. The obtained data show the decrease and exhaustion of organism regulatory mechanisms.

25-29

Authors: G.A. Aghayan, S.G. Galstyan, M.E. Mkrtchyan, G.L. Grigoryan

The presented work concerns the question of the importance of sanitary losses classification aimed to the most efficient and advanced medical aid as well as to provide the treatment at different degree of injuries. There are two well known classifications, one suggested by B.K. Leonardov and the other by L.S. Ka-minsky. However they have some defects. So, based on Kaminsky's classification we present the modified classification, requiring the presence of nominal lists qualification of methodological calculations, as well as represent information, which has an essential influence on actions planning on different stages of medical evacuation and help volume rendered during each of them.

34-37

Authors: O.Yu. Bychkova, L.A. Martimjanova

In this article it is shown the peculiarities of Domperidon treatment in patients with gastro-esophageal reflux disease (GERD) in the aspect of influence on heart rate variability (HRV). The held investigation was clearly recognized the reduction of the general HRV output in the above shown group of patient, against Domperidon intake, most of all due to high - frequency activity suppression. It seems the necessity of the careful individual drug prescribing, especially in patients with the starting low level of general spectrum output and the following profound study of domperidon influence on the neurohumoral human body regulation.

42-46

Authors: I.A. Bondarenko, N.I. Yabluchansky

The relation between parameters of the heart rate variability (HRV) and functions of an external breathing (FEB) were studied in the patients with chronic obstructive lung disease (COPD). 53 patients in the age of 60±11 years with II-IV stages of COPD were investigated. Duration of the disease on the moment of examination is 12±6 years. A control group consists of 10 persons. The estimated parameters of FEB were next: respiration rate (RR), forced exhalation volume per 1 second (FEV1), relation of FEV1 to forced vital capacity. Among the HRV parameters we estimated heart rate (HR), total power (ТР) and its components in domains of very low frequencies (VLF), low frequencies (LF), high frequencies (HF) and LF/HF ratio. The patients were divided into groups according to СOPD stage, respiration and heart rate classes, and disease duration. The results showed, that COPD are characterized by a decrease of HRV and FEB parameters, that were connected to the stage of disease, RR and HR classes and disease duration. The increase of COPD stage was characterized by equal HR and RR increase. With the increase of disease stage the HRV ТР reduced predominantly on the account оf HF. The increase of the RR and HR class was accompanied by TP reduction with concentration of changes in HF area with a proportional decrease of FEB parameters. The increase of the RR class did not influence on the HR class, whereas the increase of HR was accompanied by significant increase RR. The RR increase more than 21/minute is accompanied by HF increase and decrease of LF/HF relation . The COPD duration influences on HRV parameters in terms more than 15 years.

52-56

Authors: N.Y. Grishunina, V.V. Abramov

Neuropsychological functions and peripheral hemodynamics, vegetative provision of activity and motor activity in 110 patients with three forms of cerebral palcy (CP) has been studied. Somatic and neurologic status, vegetative provision of activity by cadiointervalography method has been perfomed. Depended on form of CP, structural characteristics of intellect, motors and vegetative desordes patients were divided into 3 groups. 1-st group (30 children) underwent adaptive physical culture-sport correction in combination with lasero-therapy. 2-nd group (34 children) underwent physical cultural-sport measures only. 3-d group - (26 children) received conventional treatment. Healthy children (20 persons) were in a control group. The results achieved testly that the use of an individual adaptive physical culture and adaptive sport complex in combination with laserotherapy favours the development of compensatory mechanisms.

60-63

Authors: I.S .Lebets, N.O. Kostyurina, O.V. Matvienko, G.V. Letyago

In most of adolescents osteoarthrosis develops against the background of systemic dysplasia of connective tissue and hypermobility of joints and is characterized by scantiness of symptoms in its clinical manifestation which are mainly arthralgias, meteopathy and crunching sounds in the joints. The development of destructive processes in connective tissue structures in the disease is indicated by significant disorders in proteoglycane and collagen metabolism, stimulated by activation of lisosomal ferments. Pathologically destructive process in girls is more pronounced than in boys.

66-73

Authors: O.M. Pasko, M.I.Yabluchansky

Aim of the study was to establish connection of heart rate variability (HRV) and external breath function (EBF) in patients with bronchial asthma (BA) with different severity and duration of BA. 61 patients with BA I-IV of the average age 53+18 years were surveyed in out-patient conditions. The EBF was estimated with the help of respiratory movements frequency per one minute (RMF), forced lung vital capacity (FLVC) and forced exhalation volume per 1 second (FEV1). For the HRV analysis heart beat frequency per one minute (HBF); spectrum total power (TP); spectrum power of very low, low, high frequencies (VLF, LF, HF) and low-frequency/high-frequency spectrum power ratio (LF/HF) were used. The increase of severity and duration BA is characterized by the coordinated changes of parameters EBF and HRV with authentic reduction of FEV1 and TP HRV basically by means of HF, that is shown by LF/HF growth, and activation of sympathetic part of nervous system.

76-78

Authors: I.D. Fedko

There were observed in out-patient department 20 male patients of 2 cole mines in Donbass with arterial hypertension, 10 of them are miners in age of 46±6 years and 10 of surface professions in age of 47±11. Clinical characteristics and level of systolic and diastolic arterial pressure after the month therapy with nebivolol with daily dose 5 mg were examined. The results showed that nebivolol with daily dose 5 mg is equally effective in miners and in those with surface professions with arterial hypertension and that is why it can be used to control arterial pressure in miners.

82-89

Authors: T.V. Sevastjanova

Report deals with the characteristics of hepatoprotectors that are currently available at pharmaceutical market. Pharmacologic analysis of classic hepatoprotector agents such as essentiale, LIV-52 and comparative new native preparations (antral, thiotriazolin and other), which have, in fact, practically no negative effect on the organism, is represented. Hepatoprotector drugs registered in Ukraine are also represented. Alongside with the main hepatoprotector action some preparations have other pharmacologic effects due to which they may be used in other branches of medical practice (cardiology, nephrology, stomatology and others). In spite of the appearance of new hepatoprotectors the problem of innumerous preparation of this group is existing. It is a base for searching of new hepatoprotector agents of synthetic and plant origin.

96-100

Authors: K.K. Vasylyev

The doktor S.F. Verbov life and activities has been lighted for the first time. Since 1920 he lived in Germany and since mid – 1930-ies in France. In his recollections published in Paris he told about Russian emigrants’ life. In his recollections published in Paris he told about Kharkov University during the first Russian revolution period.