The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

10-15

Authors: O. L. Kulik, O. J. Schmidt, S. A. S. Belal, I. A. Rank

The effectiveness of biofeedback in a closed loop of heart rate variability (HRV) and paced breathing in patients with arterial hypertension was studied. 61 subjects with arterial hypertension (31 females and 30 males, mean age 56.8 ± 6.2 years) were examined. In accordance with the objective of the study all subjects were divided into 2 groups: 1 – biofeedback group (34 subjects) and 2 – the comparison group (27 subjects). 5 biofeedback sessions were performed in biofeedback group. In the comparison group only two biofeedback sessions were performed – at admission and before discharge from the hospital. Efficacy of biofeedback was evaluated by comparing the values of systolic and diastolic blood pressure (SBP and DBP, respectively), heart rate (HR), HRV indices, indicators of optimality (O), sensitivity (S) and efficiency (E) and BQI index at admission and discharge in both groups of patients. The use of biofeedback in arterial hypertension subjects allowed to achieve better control of heart rate, systolic and diastolic blood pressure and improves HRV indices. The positive dynamics of optimality and the integral BQI values indicated a training effect of regulation systems.

21-26

Authors: M. M. Popov, O. V. Ognivenko, T. V. Sevastianova

In this paper we have studied the effectiveness of Polioksidony in the treatment of patients with chronic staphylococcus’s pharyngitis on background. It was found that the inclusion in the complex treatment of patients Polioksidony normalizes biotsinoz oropharyngeal secretions, increases the phagocytic activity of neutrophils and biocide, opsonizing properties serum normalizes the major classes of immunoglobulins in oropharyngeal secretions . Polioksidony has a positive effect on the clinical course of chronic pharyngitis and warns its recurrence, reduces the number of acute respiratory diseases and their complications.

33-37

Authors: I. V. Shanina, D. E. Volkov

The frequency of beta-blockers, amiodarone, antiplatelet agents (acetylsalicylic acid), anticoagulants (warfarin), statins, angiotensin-converting enzyme inhibitors, diuretics and angiotensin II receptor antagonists prescribing was determined in 114 patients (56 – women, 58 – men) with permanent pacemakers in VVI/VVIR (40 patients), DDD/DDDR (26 patient), cardiac resynchronization therapy (14 patients) and separate group was made up of 34 patients with sinus sick syndrome in DDD/DDDR pacing mode in 3 QRS complex duration classes: 1 – under 119 ms (normal), 2 – 120-149 ms (elongate) and more than 150 ms (significantly elongate). The patients’ average age was 69 ± 7 years. The results showed that the same groups of drugs are being prescribed as in patients with pacemakers as in patients without them. More frequent prescribing of beta-blockers was associated with prevention of the development of possible device-induced arrhythmias and chronic heart failure. More rare appointment acetylsalicylic acid and statins was associated with the lack of attention to therapeutic support. Frequency of prescribing most of used drugs in patients with implanted pacemaker increases with QRS complex duration class.

45-49

Authors: O. V. Petrenko, L. V. Bogun, M. I. Yabluchansky

A clinical case of chronotherapy of arterial hypertension is described. In patient U., according to ambulatory blood pressure monitoring (ABPM) results, 24-h average value was 145 mmHg for systolic blood pressure (SBP) and 88 mmHg for diastolic blood pressure (DBP), DBP circadian rhythm had «over dipper» pattern while SBP circadian rhythm was normal. Taking into account the daily individual BP profile the patient was prescribed antihypertensive drug lisinopril 10 mg in the morning after waking up. As a result of the treatment, after 3 months the target BP levels were achieved, but SBP and DBP pattern have been transformed into «non-dipper» ones. The treatment regimen was modified: patient was recommended daily dose of lisinopril distributed into two doses-5mg in the morningand5mg in the evening before going to bed with the subsequent control by ABPM in 3 months.

74-83

Authors: M. S. Tomin

The review presents the frequency, anatomy, classification, diagnosis, and the most effective open methods of inguinal hernia’s operative therapy in adult patients. These findings are in agreement with the recommendations of the Ukrainian association of surgeons-herniologists and the European European Hernia Society (EHS). The article does not deal with laparoendoscopic options of hernia repair (TAPP and TEP), as they require a separate section in the anatomy of the inguinal region and endoscopic techniques’ volumetric description. Besides, in Ukraine inguinal hernia repair is most frequently performed of open access that causes the topic’s timeliness.

89-94

Authors: I. V. Soldatenko

Clinical pharmacology of diuretics in the international system of ATC (anatomic-therapeutic-chemical) is presented. Classification of this group by the action mechanism and caused effects is provided. Pharmacokinetics and pharmacodynamics features, indications and principles of diuretics usage in clinics are considered. Contraindications, side effects and interaction with other drugs of this group are discussed in detail.