INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

104-114

Authors: Dr. Bharani S Sogali*, S. K. Reddy

Aim: The concept of sustained release tablet can be utilized to provide a long lasting and more reliable release of drug in GIT to ultimately develop a once daily formulation. Thus, they prolong the dosing intervals, but also increase patient compliance beyond the level of existing conventional dosage forms. Aceclofenac, an analgesic and anti-inflammatory agent is used in the management of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is a drug with short biological half-life (4 hrs) and dosing frequency more than one per day which makes it an ideal candidate for sustained release. The present investigation was planned to formulate and evaluate the Aceclofenac once daily sustained release tablets. Methodology: The tablets were p r e p a r e d b y d irect c o m p r e s s i o n meth o d and w e r e subjected for in vitro drug release studies. The mechanism of drug release was determined using various kinetic models. Results: The results revealed that all the formulated tablets had acceptable physical properties and showed release up to 24 hrs. The kinetic studies revealed that all the formulations followed Higuchi matrix model. The formulations were subjected to the comparative study of in vitro drug release with the marketed formulation, the results of which showed that the drug release from the optimized formulation showed comparatively equal to marketed product. Further the stability studies were carried out as per the ICH guidelines for three months proved that the formulated tablets were stable at the accelerated conditions of temperature and humidity. Conclusion: Based on the in vitro results it was concluded that the matrix tablets prepared with HPMC K4M, Acrycoat G971 provided the oral sustained release of Aceclofenac. Key words: Aceclofenac, Matrix tablets, Sustained release, AcrycoatG971, Hydroxy propyl methyl cellulose, Direct Compression.

129-134

Authors: Pavankumar M Sancheti 1*, Sunil P Pawar

The objective of this study was to determine the toxicity potential of three thiazolidinediones (troglitazone, rosiglitazone and pioglitazone) using in silico expert system DEREK Nexus. The chemical structures of troglitazone, rosiglitazone and pioglitazone were processed using the DEREK Nexus system on computer using all the rules in the knowledge base for predicting multiple toxicity end points in multiple species including human. DEREK Nexus was able to make predictions for all three drugs (troglitazone, rosiglitazone and pioglitazone) in the exercise. The DEREK software generated the toxicity alerts for hepatotoxicity and mitochondrial dysfunction for all three drugs. In addition, the results of troglitazone indicated alerts for carcinogenicity and skin sensitization. The level of alerts was different for different toxicity end points and species. The alert for hepatotoxicity and mitochondrial dysfunction correlated well with the information available in literature indicating its utility in prediction of the potential toxicity for the drug candidates at an early stage of development. However, it is important to note that the in silico data should be interpreted in conjunction with the in vitro and in vivo toxicity study results for the better predictivity of the potential risks to humans. Keywords: Troglitazone, Rosiglitazone, Pioglitazone, DEREK, In Silico

187-190

Authors: Asha Jyothi V*1 and Dr. Satyavati D

In the present study an attempt has been made to establish FT-IR profile and identify the functional components of Saraca asoka. FTIR method was performed on a Thermo Scientific Spectrophotometer system which was used to detect the characteristic peak values and their functional groups. The results of Saraca asoka barks FTIR analysis confirmed the presence of N-H stretching bond, alkenes group, aldehyde group, and carboxylic group which shows major peaks at 3421-3398 cm-1, 3010cm-1, 2926-2894 cm-1, and 1697 cm-1 respectively. The results of the present study produced the FTIR spectrum profile for the medicinally important plant Saraca asoka. Keywords: Saraca asoka, FTIR, Spectroscopy, Functional groups and Phytoestrogens