INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

1082-1086

Authors: Alvin Jogy , Pratibha S. Kamble , Princy L. Palatty ,Clafid Lobo, Ibel Chiramel Fredy

Despite the veritable drug explosion since the 1950s, a large number of drugs is being dispensed with a significant amount of returned drugs. Little is known of the specific details of such returns. These could be contributing as a subset of wasted medications.Indigenously prepared case records form conserning details of drugs returned was prepared and administered to the drug sales persons at various local pharmacies, after a short briefing session. This study indication that returned medicines were only a subset of the unused medications. The relevant reasons included death of the patient, wrong medication, change in medication, similar looking or sounding drugs. Key words: Returned drugs, expired drugs, similar sounding/looking drugs, drug utilization, drug policy making, discarded drug disposal

1096-1102

Authors: Loganathan Velupillai*1 , Prashant P Dixit2 , M.S. Shingare1 , D.V.Mane1 , Choudhari B R

A series of seven compounds 4-(2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)-3-fluoroaniline derivatives (5I e – 5I k) was prepared from commercially available 2-Amino-3-Hdroxy Pyridine. The morpholine, pyridine, fluorine, aniline and amides were introduced in our moiety considering the better biological results in vaster range of therapeutic area. The compound bearing such moieties gives good bio-active data. The more yield and good quality of the synthesized product was shows that there is no side reaction and by product while the organic synthesis. The structure confirmation of the synthesized molecules was confirmed by means of proton nuclear magnetic resonance spectroscopy and LC-MS spectroscopy. The synthesized NCE’s were further tested for their antibacterial and antifungal studies. Some of the molecules were identified to show better antibacterial and antifulgul activity. Keywords: Pyridine morpholine, Morpholine, Fluoroaniline, Antibacterial, Antifungal

1110-1113

Authors: A. Naga Jyothi*, E. Priyanka, D. Eswar Tony, Rama Rao Nadendla

Chamaecostus cuspidatus is commonly known as fiery costus, it is a member of costaceae, and it is a newly introduced plant in India from south-central America. The leaves of this plant are used as a dietary supplement in treatment of diabetes mellitus. A number of researches have been carried out to evaluate the antidiabetic potential of plant. It has been proven to posses various pharmacological activities on diuretics, antioxidant, antimicrobial and anti-cancerous. Key words: insulin plant, antidiabetic activity, quercetin, spiral flag.

1119-1125

Authors: A. T. Sharma*1, Dr. S. M. Vadvalkar2, S. B. Dhoot3

Immunotoxins are composed of a protein toxin connected to a binding ligand such as an antibody or growth factor. These molecules bind to surface antigens and kill cells by catalytic inhibition of protein synthesis within the cell cytosol. Immunotoxins have evolved with time and technology and recently, third generation immunotoxins are made by recombinant DNA techniques. The majority of these immunotoxins targeted antigens selectively expressed on cancer cells. It has been hoped that these agents could cause regression of malignant disease in patients. The studies carried over the plasma clearance of antibody-ricin-A-chain immunotoxins have been shown that after intravenous injection in animals of different species, immunotoxins are rapidly eliminated from the bloodstream. It is due to the mannose residues on the rich A-chain moiety which are specifically recognized by liver cells. The coadministration of yeast mannan with immunotoxin enhances the level of active immunotoxin in circulation by inhibition of liver uptake, which drastically improves the anti-cancer efficacy of immunotoxin in vivo. Immunotoxins can be given in combination with other anticancer therapies to manage tumour penetration. Immunotoxins also firmly increase the viral mortality when used along with effective anti-retroviral drugs. Besides many advantages, the development of many immunotoxins for cancer therapy has still many challenges like immunogenicity, unwanted toxicity, and difficulty in production, limited half-life, and resistance. Key words: Immunotoxins, antitumor, rDNA technique, ricin-A-chain immunotoxins, antiretroviral.

1133-1140

Authors: Arun Kumar Arumugarajan1*, G. Geetha2, Bhabani Shankar Nayak3

Background: The most prominent advantages of extended release formulations of non-steroidal anti-inflammatory drugs (NSAIDs) are their ability to maintain optimal and therapeutically effective drug levels for prolonged duration with reduction in dosing frequency and side effects associated with NSAIDs. Aim: The objective of the present study to develop diffusion controlled matrix tablets for extended release of a model NSAID drug, Etodolac. Materials and Methodology: Etodolac control release tablets were prepared by wet granulation method using Kollidon® SR in different ratios as release rate controlling polymers. The granules were evaluated for flow properties by evaluating bulk density, tapped density, Carr’s index, Hausner’s ratio and angle of repose. The tablets were evaluated for drug polymer compatibility study by FTIR, diameter, weight variation test, hardness, friability, disintegration test, in vitro drug release, release kinetics and stability studies. Results and Discussions: The FTIR study revealed that no such interactions being taking place in between drug and polymers. The flow property of granules of all tablet batches was found to be good. All the tablet formulations had good tablet physiochemical properties. In-vitro release data showed dependence of release kinetics on different percent of drug to polymer in cross-linked matrix systems. Conclusion: The results of in vitro study, it was concluded that Etodolac matrix tablet containing Kollidon® SR (10.0 %) provided most controlled release of water-soluble Etodolac over extended period of time. Keywords: Extended release, NSAIDS, Etodolac, matrix tablet, wet granulation.