863-869
FORMULATION AND EVALUATION OF PREDNISOLONE MATRIX TABLETS FOR COLON TARGETED DRUG DELIVERY SYSTEM
Authors: K. Ramesh Reddy* 1 , C.P. Sreekanth Reddy 1 , G.Saisri Harsha1 , V.Jayasankar Reddy1 P. Jayachandra Reddy 1 , K. Anil2

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The aim of this work is to formulate Prednisolone matrix tablets for colon targeting drug delivery system by using
pectin and chitosan polymers. Prednisolone is synthetic Glucocorticoids, a derivative of cortisol, which is used to
treat a variety of inflammatory and auto-immune conditions. Colon targeted drug delivery is an active area of
research for local diseases affecting the colon, as it improves the efficacy of therapeutics and enables localized
treatment, which reduces systemic toxicity. Targeted delivery of therapeutics to the colon is particularly
advantageous for the treatment of inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's
disease. Prednisolone matrix tablets were prepared by wet granulation technique by using different polymers such
as chitosan and pectin are sustained release polymers. Starch mucilage is a granulating agent .The matrix tablets
were evaluated their compatibility studies by using FT-IR, micromeritics properties, post formulation characters,
stability and in vitro dissolution studies.
Key words: Matrix tablets, Prednisolone, Pectin, Chitosan, IBD