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FORMULATION AND EVALUATION OF CONTROLLED RELEASE TABLETS OF PIOGLITAZONE
Authors: G. Ram Babu*, M. Prasad Rao, M. Rama Kotaiah , K. Ratna Rajeev
Number of views: 513
Pioglitazone Controlled release tablets were prepared by using polymers like Hydroxy propyl methyl cellulose,
Psyllium, Guar-gum, Xanthum gum and Carbopol. From this study it can be concluded that Pioglitazone C.R
tablets prepared by Hydroxy propyl methyl cellulose K15M ( i.e. H3) showed good release rate than the tablets
prepared by using other polymers. Pre compression and Carr’s index of the pure drug indicated that the drug had
good flow property, even the formulations were found to be within the range. Post compression studies, for
tablets like thickness, diameter, hardness, friability, drug content uniformity was done. The dissolution studies
were carried out for 24 hours. As per the result of dissolution study of formulation H3, P3, G3 and X3 showed
reasonable release 99.87%, 97.85%, 92.48% and 93.51% respectively at the end of 24hrs. Formula H3 showed
good drug release profile 99.87% at the 24 hrs, showed excellent matrix integrity during the period of study,
when compare to other formulations. The formulation H3 was considered optimum because it showed negligible
drug release in acidic medium and drug release in the phosphate buffer (pH 7.4) was found to be almost
complete. The stability studies of the selected formulation showed that the product was stable through-out the
study period .