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Sarcoidosis: A Multisystem Disease ‘Demystified’
Authors: 1. Dr. Bhuvan Nagpal, BDS (Gold Medalist), MDS (Oral Pathology), Consultant Oral Pathologist & Chief of Lab, Manglam Diagnostics, Hansi, Haryana - 125033 2. Dr. Priyanka Mittal, MBBS, MD (Pathology), Consultant Pathologist, Sapra Multi-Speciality Hospital, Hisar, Haryana – 125005 3. Dr. Raman Mittal, MBBS, DMRD, Consultant Radiologist, Manglam Diagnostics, Hansi, Haryana - 125033 4. Dr. Abhishek Ghosh, BDS, MDS, Assistant Professor, Dept. of Public Health Dentistry, Mithila Minority Dental College & Hospital, Mansukh Nagar, Darbhanga, Bihar, India 5. Dr. Mohamad Ayas, BDS, MDS, Consultant Dental Surgeon, Bengaluru, Karnataka. 6. Dr. Anupam Nagpal, BDS (Gold Medalist), Consultant Oral Physician & Dental Surgeon, Sapra Multi-Speciality Hospital, Hisar, Haryana – 125005 7. Dr. Anuradha Nagpal, MBBS, Consultant Physician, Hisar, Haryana – 125005
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Sarcoidosis is a multi-system granulomatous disease of unknown etiology, most commonly affecting adults and at times children. The disease characteristically causes bilateral hilar Lymphadenopathy and granulomatous, pulmonary, skin or ocular lesions. Sarcoidosis was first described in 1877 by the British surgeon dermatologist, Jonathan Hutchinson. Caesar Boeck of Oslo, Norway, fully described sarcoidosis in 1899, hence also known as Boecks sarcoidosis. Venkatraman et al 1995 reported a case of papillary psoriasis; they discussed a 50 years old man who had non-tender purplish plaques on both hands and feet. Ten years later, the classic histological pattern of the disorder was described, and it was pointed out that the syndrome of sarcoidosis involved not only the skin but also the lymph nodes, the mucous involves and the lungs. At that time the disorder received its presently accepted name Sarcoidosis. Later sarcoidosis was more formally defined as a disease characterized by the presence of non-caseating epithelioid granulomas, proceeding either to resolution or to conversion into featureless hyaline connective tissue. According to the seventh International conference on Sarcoidosis and other granulomatous disorder, the findings required for a diagnosis of sarcoidosis include:
Clinico-radiographic evidence of multiple organ involvement, usually amplified bilateral hilar lymphadenopathy
Pulmonary infiltration
Pathological evidence of widespread non-caseating and non-infectious granulomas