JOURNAL OF FUNDAMENTAL PHARMACEUTICAL RESEARCH

4

Authors: Hirumani Bhuyan1 , Smriti Rekha Chanda Das

In this study the anthelmintic activity of Houttuynia cordata leaves was evaluated using Pheretima posthuma (earth worm) as test worms. Three different concentrations of ethanolic extract of H. cordata leaves were taken (10, 20, 50mg/ml) and tested for anthelmintic activity which mainly involved the determination of time of paralysis and time of death of the worms. Albendazole at varying concentrations (10, 20 and 50mg/ml) was taken as the standard reference and normal saline was used as the control. The result of the present study shows that the ethanolic extract of Houttuynia cordata leaves showed profound anthelmintic activity against tested worm species. It justifies its folklore use in curing helmintic infections. Further studies are needed to establish the mechanism of action responsible for the concerned activity.

13

Authors: Basu Aalok1, Ghosh Amitava2, Malakar Jadupati2

Nanoparticles have attracted the attention of many research groups and have been utilized in quite a number of areas during the last few years. In general, two main strategies are used for their preparation: the dispersion of preformed polymers and the polymerization of monomers. Different techniques may be used to prepare the polymer nanoparticles, such as solvent evaporation, salting-out, supercritical fluid technology, micro-emulsion and mini-emulsion. The choice of technique is based on a number of factors, for example, particle size, particle size distribution, area of application, etc. This review attempts to provide the general description of the preparation, characterization and applications of nanoparticles.

19

Authors: Prabir Kumar Datta1*, Jasmina Khanam2, Amitava Ghosh1, Goutam Mukhopadhyay3

There exists a common idea that toxic chemicals are generally produced by chemical industries. While pharmaceutical industries are the only producers of antidotes and medicines to cure ailment of the patient. The pharmaceutical industries have shown a rapid growth in last few decades with the advent of latest G.M.P. and automation, but advancement in the field of pollution control in pharmaceutical plants still found to be sluggish, particularly in developing countries. This article will provide information to technical personnel of pharmaceutical industries regarding different toxic pollutants generated during the operation of pharmaceutical plants and their control based on commercial feasibility. Different ways of pollution control like waste minimization from the source, recycling and reuse, control of dusts and toxic volatile gases from boiler and production plants by filter and adsorbents , use of aqueous coating technology for reduction of chlorinated hydrocarbon in air, control of spilled materials in storage and processing areas have been discussed. Various technologies and devices have been mentioned for pollution control of waste water like Bar Screen, Flocculation, Sedimentation, Gravity Coagulation, Adsorptive Bubble separation, Activated Sludge Process, Trickling Filter, Aerated Lagoons, Reverse Osmosis, Ultra Filtration, Ion Exchange Resin, and Membrane Filtration. After treatment water can be reused for pharmaceutical production.