The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

9-15

Authors: L. A. Yurchenko

Determinated haemolitics and lecithinase activity 80 cultures of Proteus, abstracted from the different hearts of infection; the cultures from pathological material had greater haemolitics activity as compared rela-tively transmitters. A hard defined medium with properties swarming inhibition, which didn’t inhibition acti-vity Proteus for haemolitics of erythrocytes, is developed. Dependences of haemolytic or lecithinase activity of Proteus from its finding in O- or the H-form not revealed.

22-29

Authors: A. N. Boiko

The content of proinflammatory cytokine is increased in blood of the patients with helicobacter pylori – negative gastropathies and with chronic heart failure (CHF) of an ischemic genesis. This confirms the theory of existence of the system inflammatory answer at this category of patients. 105 patients with essential arterial hypertension and CHF of II and III functional classes with helicobacter pylori – negative gastropathies with the mediana of age 54 years were examined. It was established that degree of rising blood concentration of such cytokines as IL-1 and the TNF-1 has direct dependence with stages of CHF. The analysis of the re¬ceived results gave us the evidence that patients with CHF and helicobacter pylori – negative gastropathies have significantly higher levels of proinflammatory cytokines and ET-1 in comparison with patients without gastropathy. Also the blood level of PGF1 was significantly smaller at this group. Thus, the development of gastropathy at the patients with arterial hypertension of 2 degree and with CHF is associated with activation of an immune inflammation and increasing disturbance of an endothelium functional condition. Significant differences at the patients with various level of cardiovascular risk were revealed only for the blood TNF-1 content. This fact confirms the strong connection between this indicator and the forecast for the given category of patients.

37-42

Authors: N. G. Gravirovska, О. I. Zalyubovskа

During examination of the regional indexes of prevalence and morbidity of duodenum peptic ulcer (PU) in Kharkov and Dnepropetrovsk regions and tendency of their development, the high growth rates of PU prevalence in Ukraine as well as in indicated above regions has been determined. Regional domination of PU morbidity growth rate in Khakov region has been established. It exceeds the similar index in Ukraine by 87 % with maximum increasing in 2004 by 63, 6 %. Reducing of the number of first time diagnosed PU cases in subsequent years can be explained not only by more effective medical technologies but also by the lack of diagnostic capabilities of medical service, imperfect management of the patients at the dispensary observation stage that leads to an increase of severe complications and necessity of surgical intervention.

46-49

Authors: A. А. Zazdravnov

In this article author analysed the corellation of anemia and gastroesophageal refluxe disease (GERD) by patients with rheumatoid arthritis (RA). Author offers personal experiences (110 cases). The main patho-genetic links of anemias and heterogeneity of anemia in patients with rheumatoid arthritis have been elucidated. The frequency of occurrence of GERD and pathogenetic mechanisms of GERD in these patients were studied. Relationship between anemia and GERD in patients with RA has been established.

52-60

Authors: M. P. Kopytsya, N. V. Tytarenko, N. V. Bila, O. L. Oparin

The aim of this study was to define the utility of the measurement N-terminal pro-brain natriuretic peptide (NTproBNP) and other clinical and biochemical markers to predict adverse events at 1 year in patients with ACS. Parameters with significant differences in died and surviving patients were taken for analysis: age, heart rate (HR) at admission, levels of hemoglobin and NTproBNP. Curves of sensitivity and specificity were used based on the method of ROC analysis and cut-off values were chosen for each variable. Ball scoring was per-formed for each parameter regard to the cut-off value and a scale for calculating the summarized diagnostic coefficient (DC) by the method of Gubler was offered. A multimarker approach included on NTproBNP, hemoglobin, HR at admission and age and the summation of balls based on offered scale and calculating DC provides information in terms of ACS prognosis at 1 year, with a worse outcome for those with diagnostic coefficient has positive value (sensitivity 88,9 % and specificity 93,8 %).

66-71

Authors: T. V. Lukyanenko

The article presents the research results of the antistreptolysin O, antihyaluronidase, complement, and lysozyme levels in patients with alcoholic delirium complicated and not complicated by community-acquired pneumonia. Antistreptolysin O and antihyaluronidase levels in patients with pneumonia are above the norm and correlated with the severity of community-acquired pneumonia course. The complement and lysozyme titers are below the norm. We consider this to arise from the prolonged course of alcoholism, frequent bacte-rial complications caused by associations of mircroorganisms, including Streptococcus sp. The bacterial complications for this category of patients are caused by the microflora with a considerable level of antilysozyme and anticomplementary activity. The data we obtained may be used for prognosticating the infectious complications in patients with alcoholic delirium.

76-83

Authors: G. M. Fomych, N. I. Yabluchanskiy, L. A. Martimyanova

A relationship between different types of orthostatic reactions (OR) of ventricular rate (VR) and clinical ma¬nifestation of permanent atrial fibrillation (AF) in 73 patients (32 men and 41 women) aged (55 ± 15) years with a prescription AF (6 ± 5) years has been studied. All types of OR have been noticed in studied popu-lation. Positive OR of VR have been dominated (41 %), negative and absent OR of VR have been occurred more rarely (34 % and 25 % respectively). Qualified positive OR of VR have been occurred in 27 %, and negative – 40 % of patients. High incidence of prognostically less favorable qualified negative, positive and absent OR of VR in elderly and senile patients with AF requires closer attention with more precise exami¬na-tion, drug therapy and lifestyle modification of patients.

88-104

Authors: A. М. Yabluchanskiy

Intracerebral hemorrhage remains one of the less studied problems in modern neurology. Later pub-lications suggest that inflammatory processes play a significant role in hemorrhagic stroke; however, most of these reports represent fragmentary information on the local and less system levels of inflammation, and do not show the correlation between these levels. In this review the attention is focused on the compensatory, adap¬tive and restorative nature of the inflammation in the post-intracerebral hemorrhage damage. Non-complicated and complicated forms of inflammation are discussed regarding their influence on the course and outcomes of hemorrhagic stroke. Optimization of complicated inflammation could be one of the approaches for improving the outcomes of hemorrhagic stroke.