The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

5-11

Authors: E.Yu. Isaenko, E.M. Babych, T.V. Gorbach, Yu.L. Volyansky, A.V. Martynov, N.V. Caspur, V.S. Antipov

The influence of ultrasound in middle- and high-frequency ranges, which to statistically significant changes of optical density of suspensions and reliable reduction amount of living cells B. рertussis is investigated. The clearing of ultrasound disintegrator by centrifugation and filtration through membranian filters is done. These actions have allowed to clear antigens from low-molecular chemical structures. Ultrasonic disintegrators with the lipid fractions in their structure are allocated. Also protein structures with the molecular weight from < 1 up to ≥1000 кDа are allocated.

15-21

Authors: K.A. Apykhtin, A.V. Shvets

For revealing of influence features of «Vitam» prophylactics course on information and neurovegetative components of operator’s highly reliability activity investigates 23 operators of the Call-centre in psycho-emotion simulated conditions model have been investigated. The psychophysiological functions of dynamic memorizing, moving object reactions, short-term memory and attention quality for a different level of complexity have been studied. There was performed research about influencing of vitamin-mineral complex «Vitam» on the vegetative neuro-humoral adjusting of cardiac rhythm and objective indexes of mental capacity in the operators. It was found stress-protective effect (by reduction of amplitude of neuro-vegetative displays of stress reaction) and effect of mental work reliability improvement.

34-38

Authors: M.M. Korenev, L.I. Rak

Objective: To establish the character of changes in protein peroxidation (PP) and antioxidative defense (AD) in children with myocardial pathologies (MP) at early stages of chronic cardiac insufficiency formation. There were examined 283 children, aged 10-18 (mean age 14,86±0,15 yr), with MP: myocardiofibrosis (n=54), dysplastic cardiomyopathy (n=56), dilatational cardiomyopathy (n=6), hypertrophic cardiomyopathy (n=12), rhythm disorders (n=141), and myocardium overstrain syndrome (n=14). 67 practically healthy chil-dren of the same age served as a control group. There were studied cardiac morphofunctional characteristics (ECG, echoCG), carbonylated proteins content, as well as superoxiddysmutase (SOD) and glutathione peroxidase (GP) activity. It was established that in all variants of myocardial pathology in children there was observed an activation of PP process, more pronounced in cases of primary cardiomyopathy. The process was accompanied by differently directed changes in the system of AD: an increase in GP activity in cases of hypertrophic cardiomyopathy, a tendency to a certain decrease in SOD activity in cases of primary cardio-myopathy, and a decrease in GP activity in the myocardium overstrain syndrome. At the initial signs of cardiac insufficiency an activation of antioxidative system was observed that could be an indirect evidence of intensification of free radical processes.

46-52

Authors: O.M. Ovcharova, N.A. Tkach, L.S. Mkhitaryan, T.I. Gavrilenko, T.V. Ponomareva

We studied 391 patient with congestive heart failure (CHF) and left ventricle systolic dysfunction (LVSD) (LV ejection fraction<40%) with coronary heart disease (CHD) (265 patients) and dilated cardiomyopathy (DCMP) (126 patients) within ІІ-IV functional class (FC) by NYHA. In 171 patients with CHD we found concomitant arterial hypertension (AH). The objective of the study was to compare levels of laboratory indices that mark systemic metabolic violations, immune inflammatory reaction and lipid peroxidation in the patients with CHFdue to DCMP and CHD, with concomitant AH inclusively. In CHD group we found bigger segment of patients with decreased glomerular filtration rate <90 ml/min. and anemia compared to DCMP. These differences are explained by age discrepancy and age morphological and functional renal changes in patients with CHD rather than by etiology of CHF. In the patients with CHF due to DCMP we found lower lipids panel levels, while in the patients with CHD we saw more often hypercholestrolemia, which matches with age and pathogenetic peculiarities of patients with CHD and DCMP. Cytokine link of immune inflammatory response and lipid peroxidation in the patients of the studied groups did not differ, except the level of serum malonic dialdehyde, which was significantly higher in the patients with CHD compared to those with DCMP.

56-62

Authors: A.I. Choporova

Рresents the data about condition of oxidant-antioxidant systems, metabolic intoxication, connection of their pathological shifts with clinical manifestation of tuberculosis of lungs, biochemical signs of disturbances of liver function. It is shown, that the level МDA of blood allows to reliably judge about condition of the patient, current of disease, to predict quality of clinical treatment of tuberculosis and probability of development during polyсhemotherapy of biochemical shifts of signs of liver function. It is established, that application of glutargin in complex treatment of patients suffered from tuberculosis allows to eliminate displays of metabolic intoxication, make of correction of balance oxidant-antioxidant systems that can be regarded as confirmation of scientific validity of his clinical application.

73-81

Authors: І.Yu. Burdа, N.V. Lysenko, M.I. Iabluchanskyi

QRS complex plays an important role in heart work. Changes of its duration by shortening or prolonga-tion cause serious difficulties in electrophysiology and biomechanics of the heart. Recent publications concerning changes of QRS complex duration in different cardiovascular diseases are given. The electrophysiology, biochemistry and biomechanical implementation of QRS complex and factors that influence its duration are discussed. The causes and mechanisms of changes of QRS complex duration during cardiovascular diseases are considered. It is emphasized that QRS complex duration influences not only clinical status, but also prognosis of the patients with cardiovascular diseases.