The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

9-14

Authors: L.S. Godlevsky, K.I. Stepanenko

Paleocerebellar cortex (nodulus and uvula) was electrically stimulated (ES) in one group of male Wistarrats, while another group was amydalarly kindled and one more group was sham operated. Just only kindledgeneralized clonic-tonic seizures were followed by a net increase of the TNF-. content both in hemispheres (from 34,7+6,0 up to 76,7+6,9 pg/mg of wet brain tissue) and cerebellum (from 106,6+17,7 up to 193,8+29,8 pg/mg of wet tissue) in comparison with data from sham. operated animals. ES of cerebellum (100 Hz) was not followed by changes in TNF-. content both in cortex and cerebellum. Meanwhile, kindling was not followed by changes in thiol/disulfide system changes, but ES of paleocerebellum caused a significant rise offree thiol groups in cortical tissue. Besides, paleocerebellar ES was followed by increase of incorporation ofC14 methionine by ventral hippocampal structures, and H3 triptophane by ventral hippocampus, brain stam and “rest” tissue of brain as well.

19-22

Authors: E.V. Sirenko

The condition of oxidation-restoring processes of white rats in prasence of phlotoreagent was studied insubcute experiment. The statisticaly trustworthy datas of activity membranospecific lipidodepended enzymesand transport ATPH-acid of blood and tissues of white rats was registered. The degree of dependence of biochemical datas disoders from doses of organic substance was revealed. Experimental datas confirms thefact of disoders bioenergetic processes of cells and negative influance of phlotoreagent «OIB IBS» onoxidation-restoring processes in organism of warm-blooded animals.

31-34

Authors: N.P. Kopitsa

It has been studied the influence of interleukin-6 (IL-6) and C-reactive protein (CRP) on the frequency ofsudden cardiac death in 80 patients after myocardial infarction (MI). The average age of patients was (58±15) years old, they involved 72 men and 8 women. The initial concentration of IL-6 in early afterinfarction periodin patients who had died suddenly during 12-month observation differed significantly from the similar data insurvived - (220±47) pg/ml versus (118±15) pg/ml (p<0,001). The same results was obtained towards CRP - (6,2±1,8) pg/ml in patients with sudden cardiac death (SCD) and (3,0±1,3) pg/ml - in survived (p<0,001). Thereby, we have done conclusions that IL-6 and CRP levels decrease in patients after MI should be high riskof SCD data.

41-45

Authors: I.E. Sedakov, E.D. Yakubenko, I.I. Zinkovych

On the basis of 5-years observation of 84 advanced breast cancer cases was shown that the diseaseprogression was more rarely in the patients were appeared the reduction of lipid peroxidation rate and declined in the serum.-tocopherol level in response to intra-arterial chemotherapy course. Such patterns werenot registered for antioxidant enzymes.

51-59

Authors: O. Cudoma

The aim of our investigation was to evaluate the possibilities of transvaginal echography (TVE) withdopplerography in diagnosis of adenomyosis dependong of age, fertility and type of desease. The objects ofinvestigation were 134 patients with adenomyosis and infertility and 200 patients with undisturbed fertility. TVE with dopplerography (colour and power doppler) was fulfilled on ultrasound equipment HDI 1500 (ATL). In patients with adenomyosis more often there were such echographic symptoms as increase of uterinesize, abnormal M-echo, zone of increased echogenisity, disturbed doppler vascularity of myometrium andendometrium. In patients with infertility and normal fertility there were differences in echographis anddopplerographic treats of endometrial and subendometrisl zone: B-structure of endometrium and 2nd type of endometrium vascularisation was more often seen and the 3rd and 4th type more rare seen in patients withinfertility. May be these echographic symptoms reflect the pathological changes in endometrium which can be the cause of infertility. The worsen doppler blood flow indices in ovarian stromal vessels in patients ofadvanced age with adenomyosis occurs due to the influence of age on ovarian reserve, the increase in RI and PI in endometrial vessels due to more prolonged existence of disease. So, TVE with doppler ultrasoundmeasurement of uterine and ovarian blood flow can improve the diagnosis of adenomyosis and be helpful in receiving additional information in patients with infertility.

63-168

Authors: "COMPUTER MEDICINE'2004: CLINICAL INFORMATICS AND TELEMEDICINE"

"COMPUTER MEDICINE'2004: CLINICAL INFORMATICS AND TELEMEDICINE"