The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

5-9

Authors: Alumuku M., Okonjo C., Hazem O., Belal S. A. S.

In 102 conditionally healthy volunteers aged from 19 to 30 years (average age is 19,53 ± 11 years) the volatility of heart rate variability (HRV) spectral parameters depending on body mass index (BMI) were evaluated. According to WHO recommendations on the calculation and interpretation of BMI were such groups of volunteers: underweight, normal body weight, overweight, obesity I degree, obesity II degree, obesity III degree. Among HRV parameters were evaluated total power (TP, ms2), power of very low frequency (VLF, ms2), low frequency (LF, ms2) and high frequency (HF, ms2) domains of HRV spectrum in the 5-minute intervals of ECG in I standard lead. The data were processed by methods of nonparametric statistics. It was established that spectral characteristics of HRV in volunteers with normal BMI have a high TP with harmonious relations between VLF, LF and HF domains; decreased or increased BMI provokes TP reduction by decreasing power of all domains of HRV (VLF, LF, HF) with a predominance of VLF proportion and this effect increases with the degree of deviation of the parameter.

18-22

Authors: Lebets I. S., Zaytseva E. M., Letyago G. V.

The purpose of the study was to investigate the clinical symptoms and evolution of juvenile chronic arthritis (JCA) at different stages of it development. 39 children with duration of JCA from 6 months to 5 years in age from 2 to 18 years were examined. All patients underwent clinical examination, indicators of acute phase of inflammation (CRP, sialic acid, seromucoid, glycoproteins), rheumatoid factor, circulating immune complexes, complement, instrumental methods (X-ray and ultrasound, capillaroscopy of nail bed) were evaluated. Activity of the disease was estimated by disease activity score (DAS28). Statistically was determined the relative value (P). It was found that the disease started with monoarthritis (63,37 %). In the future, in half of the patients was formed oligoarthritis with damaging of large and medium-sized joints (68,25 %). In the majority of surveyed disease occurred against the backdrop of the minimal activity of the inflammatory process. On the stages of evolution recurrence of arthritis were observed in one third of children. If duration of the sickness is more than 5 years, it has become less frequent, than in previous years. The absence of clinical and radiographic manifestations of JCA after the abolition of medical treatment within one year, became the basis for the assumption that the disease remission, which was on the third year of the disease 25,93 %, on the fourth – 33,33 %, on the fifth – 36,36 %. The absence of radiographic signs of bone destruction, disability of patients allows interpreting JCA as a positive option of chronic juvenile idiopathic arthritis.

29-31

Authors: Radchenko A. O., Belal S. A. S., Nazarenko E. O.

On 13 conditionally healthy volunteers aged from 18 to 46 years (mean age – 22±7,6 years) the variability of the total power (TP, ms2) of the spectrum, very low frequency (VLF, ms2), low frequency (LF, ms2) and high frequency (HF, ms2) domains of heart rate variability (HRV) in 5 minute intervals of ECG in I standard lead before and 30 minutes after oral admission of 500 mg of mebicar were evaluated. The data were processed by methods of nonparametric statistics. No significant changes in TP, VLF, LF, HF HRV after 30 minutes (maximum time declared by pharmacodynamics action) after administration of 500 mg of mebicar were noted by us. Accordingly, the effectiveness of mebicar as an adaptogen without evidence-based research cannot be postulated.

37-42

Authors: Abiodun M. A., Adegoke E. A., Aduroja A. O., Petrenko O. V.

A clinical case of arterial hypertension (AH) in patient with family history of pheochromocytoma is described. Patient has no classical clinical signs and imaging phenotype of pheochromocytoma, but there are a number of warnings – family history of pheochromocytoma, prevalence of humoral-metabolic regulation and reduced reaction to the respiratory test, CT-signs of nodular hyperplasia of left adrenal gland – which may indicate its possible manifestations in the future, and therefore the monitoring is required.

48-52

Authors: Lakhonina A. I., Filatova A. V., Makienko N. V., Vodyanitska N. A.

Aspects of diagnosis, difficulties in the diagnosis and optimal therapeutic strategies in patient with hypertrophic cardiomyopathy and comorbid conditions such as arterial hypertension, ischemic heart disease, dyslipidemia, diabetes mellitus type 2, stenosis of the left renal artery, obesity are reviewed on the example of clinical case. Hypertrophic cardiomyopathy combined with multimorbidity conditions requires a high-quality medical management, where the main goal is to improve the quality and duration of patient's life. This goal is being achieved by optimizing patient's lifestyle and assigning only the minimum amount of medications. Necessity of careful diagnosis of hypertrophic cardiomyopathy, evaluation of the risk of sudden death and search of optimal treatment in patients with multimorbidity pathology are demonstrated in clinical case.

58-60

Authors: Sharif B. J. R., Liuta E. A.

Acquired heart disease complicated by chronic heart failure (CHF), which significantly impairs the quality of life of patients and worsens the prognosis and remains radical surgical treatment with implantation of prosthetic valve. On the example of a clinical case are shown and discussed the results of a late replacement of the mitral valve in patient with acquired heart defect.

66-69

Authors: Zolotarova T. V., Maroun B., Hanan S., Mehtieva F. B.

The clinical case an adult patient with rare genetically heterogeneous disorder combine with congenital heart diseases and multiple stigmas of disembryogenesis, currently presenting mostly with signs of pulmonary hypertension have been reviewed. Patient is presented with definitive Noonan’s syndrome according scoring system of Van Der Burgt (has 2 major criteria). The data of the laboratory and instrumental diagnostic methods, clinical diagnosis, selection of the optimized treatment and modification of the habit of life are given.

88-101

Authors: Pochinska M. V.

Clinical importance of the pulse pressure (PP) in patients with permanent pacemaker (PM) is discussed in this review. Clinical characteristics, hemodynamic parameters, stimulation parameters, depending on the PP, and the ability to optimize medication with antihypertensive drugs are considered. Implanted pacemaker and CRT are changing the PP, which substantiates the need for additional medical supervision.