The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

9-15

Authors: Kolomytseva I. M.

162 patients (89 men and 73 women) aged 69 ± 10 years were observed at the annual stage of supportive drug therapy after implantation of pacemakers in DDD/DDDR, VVI/VVIR and CRT-P/CRT-D modes. Changes of hemodynamic parameters were taken in consideration according to the functional class of chronic heart failure (CHF FC). Pacemakers implantation and supportive drug therapy led to transference of patients to the lower CHF FC with more significant results in CRT-P/CRT-D mode, normalization of heart rate (HR) in all CHF FC and stimulation modes, systolic (SBP) and diastolic blood pressure (DBP) in DDD/DDDR and CRT-P/CRT-D modes, end-systolic and diastolic volumes (EDV and ESV LV), left ventricular ejection fraction (LVEF) in CHF FC II in all stimulation modes and CHF FC III in DDD/DDDR and VVI/VVIR modes and size of the left atrium (LA) in CHF FC II in all stimulation modes and CHF FC I in VVI/VVIR mode. In thickness of posterior wall and interventricular septum of the left ventricle (LV PW and IVS), the sizes of the right atrium (RA) and right ventricle (RV) significant changes in any of CHF FC were not noticed, which requires drug therapy amplification. KEY WORDS: permanent pacing, сchronic heart failure, functional class of сchronic heart failure, hemodynamic parameters, annual stage, drug therapy

21-24

Authors: Petrenko O. V., Yabluchansky M. I.

The systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) daily profiles incidence was studied in 53 patients with arterial hypertension. A significant difference in the frequency of occurrence of different types of SBP, DBP and PP daily profile was revealed. In the structure of SBP daily profile «nondipper» and «dipper» types were dominated, DBP - «dipper» and «overdipper» types, PP - «night-picker» type. The conclusion about the need to evaluate not only the SBP circadian pattern, but DBP and PP also to improve the quality of arterial hypertension diagnosis, prognosis and treatment was made. KEY WORDS: ambulatory blood pressure monitoring, systolic blood pressure, diastolic blood pressure, pulse pressure, daily blood pressure

30-33

Authors: Rudenko T. A.

A role of blood glucose levels in the development of interstitial collagen has been studied in 84 patients (53 women and 31 men, average age 60 ± 2.4 years) with coronary heart disease (CHD). All patients were divided into twocomparable groups: a study group including patients with coronary heart disease andtype 2 diabetes mellitus (DM) and a control group consisting of patients with coronary heart disease without DM. All patients received standard medical therapy as recommended by the European Society of Cardiology. The level of blood glucose in both groups was assessed by the standard technique, a degree of interstitial collagen volume fraction (ICVF) was measured using the formula of J. Shirani et al. The data were processed by parametric and nonparametric statistical methods. It has been proved that hyperglycemia in type 2 diabetes contributes to the development of ICVF, the degree of which increases with the rise of blood glucose level. A high level ofICVF in patients with coronary heart disease and diabetes type 2 can be a predictor of myocardial dyssynchrony development and heart failure progression, therefore, a close monitoring and timely correction of changes of blood glucose levelsare recommended to prevent the complication development. ICVF evaluation should become a routine diagnostic method in all patients with type 2 diabetes. KEY WORDS: interstitial collagen volume fraction, type 2 diabetes mellitus, coronary heart disease

41-44

Authors: Tselik N. E., Shevchuk M. I., Martynenko A. V.

The relationship between the duration of the complex QTc ECG and clinical signs of arterial hypertension (AH) in 54 patients (16 men and 38 women) 1-3 degree and I-III stage, mean age 58 ± 18 years, was investigated. 3 classes of QT interval duration were allocated: classified shortened (< 320 ms), normal (> 320 ms and < 440 ms), classified prolonged (> 440 ms). The binomial distribution of frequencies of studied parameters in classes of the QTc interval for alternative criteria was determined. The duration of the QTc interval in the sampling was 350 ms – 490 ms. The proportion of the normal range (> 320 ms and < 440 ms) was 0.85, classified prolonged (> 440 ms) – 0.15. The probability of occurrence of QTc prolongation ECG increased in elderly patients, obesity, abusing of alcohol, mild and moderate degree and stage II AH, diabetes mellitus, atherosclerotic cardiosclerosis, stable angina functional class (FC) II, HF FC III and II A stage. Dependencies of the elongated QTc of ECG from the sex of the patients have not been established. KEY WORDS: arterial hypertension, duration of the QTc interval of ECG

49-56

Authors: Makharynska O. S., Zhuravka N. V.

HMG-CoA reductase inhibitors (statins) are the most prescribed class of drugs in the world. Some authors suggest that positive effects of statins were reported for statins against pneumonia. These positive studies data were counterbalanced by at least one negative prospective cohort study. Where lies the truth? Better understanding the statins influence and their potential role in pathophysiological pneumonia mechanisms is needed because of high quantity of subjects receiving statins with numerous medical conditions significantly associated with increased short-term mortality. KEY WORDS: statins, pneumonia, outcomes, statin effects