Journal of Pharmaceutical, Chemical and Biological Sciences

04

Authors: S Balamuruganvelu, B Geethavani, KR Premlal, S Jaikumar, M Kalyani, S Sengottuvelu**

Polyalthia longifolia is native to the drier regions and commonly used in for the treatment of various ailments including constipation. The present study was carried out to investigate the laxative activity of Polyalthia longifolia bark in albino’s Wistar rats. The animals were divided in to 4 groups of 6 rats in each group. Group I, served as control received saline (1 ml/kg, p. o.), Group II served as reference control received sodium picosulfate (5 mg/kg, p.o) and groups III and IV received 200 and 400 mg/kg of ethanolic extract of Polyalthia longifolia bark extract respectively through oral administration. The laxative activity was determined based on the total weight of normal as well as wet faeces production in all 4 groups was monitored for 16 h. The ethanolic extract of Polyalthia longifolia enhanced the wet faces production at the doses of 200 and 400 mg/kg. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). Conclusions: The results showed that the ethanolic extract of Polyalthia longifolia bark has a significant laxative activity and supports its traditional use in herbal medicine.

10

Authors: Sumit Das*, Ripunjoy Bordoloi, Nishant Newar

The Immune System is the most complex biological systems in the body. At the time of infection immune system go under the attack of a large number of viruses, bacteria and fungi. The immune system is a part of body to detect the pathogen by using a specific receptor to produce immediately response by the activation of immune components cells, cytokines, chemokines and also release of inflammatory mediator. They modulate and potentiate the immune system. Medicinal plants impart significant roles in the prevention of human being from various pathogenic microorganisms and the diseases. In nature there are various medicinal plants which are used as immune modulator agents. Certain medicinal plants are believed to promote positive health and maintain organic resistance against infection by re-establishing body equilibrium and conditioning the body tissues. It is tempting to speculate that the restorative and rejuvenating power of these herbal remedies might be due to their action on the immune system and some of the medicinal plants are believed to enhance the natural resistance of the body to infections. Plant derived materials (proteins, lections, polysaccharides, etc.) have been shown to stimulate the immune system. Ayurveda and other Indian literature mention the use of plants in treatment of various human ailments. There are a number of plants that have been reported to have immune modulatory activity. The present paper review plants which have shown experimental and clinical immune modulatory activity.