Journal of Science and Applications: Biomedicine

83-87

Authors: Yan Li, Jichun Li

The objective of this study is to analyze the 42 cases of mesh erosion in total 1036 female pelvic flood dysfunction (FPFD) patients who accepted the Pelvic Reconstructive Surgery by mesh-replacement materials. 1036 patients who received pelvic organ reconstructive surgery from June, 2006 to Jan, 2015 were reviewed, including general condition, surgery records, in-patient conditions and follow up. The follow up time ranged from 3 to106 months, with the average time of 45.8±2.9 months. The erosion rate was 4.05 % (42/1036). The erosion took place from 1 to 48 months after surgery. The mean time of erosion took placed was 11.4±2.8 months. There were no significant differences in patients’ age, times of pregnancy, whether menopause, whether replacement therapy (RT) and the stage of POP and SUI, however the rate of erosion is slightly higher in patients with ages ranging from 50s to 60s. No erosion case was found in the simple TVT-O group. There was no significant difference between TVH altogether and no TVH (P>0.05). There was no significant difference with or without TVT-O together (P>0.05), but the rate in total pelvic reconstruction is obviously higher than anterior pelvic construction surgery (P<0.05). In total 42 cases, 71.4% (30/42) happened in anterior vaginal wall, 21.4% (9/42) happened in posterior vaginal wall, 4.8% (2/42) happened in both anterior and posterior vaginal wall. 2.4% (1/42) happened in the puncture path of the two thigh root. The erosion rate in anterior vaginal wall is obviously higher than posterior wall (P<0.05). There were no erosion happened in bladder or rectum. In all 42 erosion cases, 80.9% (34/42) had vaginitis (include acute and chronic). In conclusion, most erosion happened in the vaginal wall, especially the anterior vaginal wall. The best therapy for mesh erosion is to remove the mesh by surgery. Infection is the main cause of erosion post operatively.

96-104

Authors: Guoming Su, June Wang, Li Zhou, Chuncai Hu, Weiqing Yang *, Zuguo Zhao

Several studies have been conducted to examine the association between miR-608 (rs4919510) gene polymorphism and cancer risk, but the conclusions remain controversial. The aim of our study was to investigate whether miR-608 rs4919510 polymorphism is associated with the risk of cancer. We conducted a search of PUBMED, EMBASE and the Cochrane Library up to April 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were determined as measures of the strength of association between miR-608 rs4919510 polymorphism and cancer risk. The combined results based on all studies showed that miR-608 (rs4919510) gene polymorphism had a statistically significant decreased risk of cancer development under four comparison models (C versus G: p ＜ 0.001; CC versus GG: p ＜ 0.001; CC+GC versus GG: p = 0.034; CC versus GC+GG: p ＜ 0.001). Among Asian subgroups, the combined results showed that a statistically significant decreased risk of cancer development was observed under three comparison models (C versus G: p = 0.026; CC versus GG: p = 0.018; CC versus GC+GG: p ＜ 0.001). The pooled results of this meta-analysis suggested that the CC genotype of the rs4919510 polymorphism within hsa-mir-608 was significantly associated with a decreased risk of cancer among Asians.