Journal of Science and Applications: Biomedicine

26-32

Authors: Chunbo Li 1*, Yuping Gong 2

Pelvic organ prolapse (POP) is a common disorder affecting the quality of life for millions of women worldwide. Effective surgical procedures involving synthetic permanent meshes exist, but significant short- and long-term complications occur. Stem cell-based tissue engineering presents an alternative approach, which aims at repairing the anatomical components of pelvic supporting structures. However, the vagina is a complex organ with great demands of functionality, and the perfect match of scaffold, cells, trophic factors and animal model has yet to be found and tested in preclinical studies. Therefore, new research directions include the usage of bioactive materials, the application of seed cell, and the usage of various trophic factors may help facilitate integration of the new tissue. More research with detailed in vivo and long term testing is needed to ascertain the most successful and safe methods and materials for POP.

19-23

Authors: Dong Chen, Yining Li

We aimed to estimate the prevalence of overactive bladder (OAB) in South of China, to assess the variation in prevalence by sex and age, and to measure the impact of OAB on quality of life. A population-based, cross-sectional telephone survey was conducted with a questionnaire regarding the prevalence of OAB, demographics, and the impact of OAB on quality of life. A geographically stratified random sample of men and women aged ≥30 years was selected. The overall prevalence of OAB was 26.5% (male, 18%; female, 28.7%). Of a total of 265 participants with OAB, 36.8% and 18.2% reported moderate or severe impact on their daily life and sexual life (6.5% and 2.9%, respectively, in participants without OAB). Anxiety and depression were reported by 21.2% and 38.3% of participants with OAB, respectively (8.9% and 23.6%, respectively, in participants without OAB). Only 23.5% of participants with OAB had consulted a doctor for their voiding symptoms, but 45.6% of respondents with OAB were willing to visit a hospital for the management of their OAB symptoms. This study confirmed that OAB symptoms are highly prevalent in Korea, and many sufferers appear to have actively sought medical help. OAB has severe effects on daily and sexual life as well as psychological health.

8-14

Authors: Li Xue, Tie Chong, Qi Chen, Hecheng Li, Peng Zhang, Zhenlong Wang, Ziming Wang*

The purpose of this study is to assess functional and morphologic recovery in children after dismembered pyeloplasty for GH caused by UPJO of children. From Jan 2005 to Dec 2010, 38 pediatric patients with GH who underwent dismembered pyeloplasty performed by a single surgeon were retrospectively analyzed. Patient follow-up was at least 3 years. The outcomes of different types of UPJO were compared. DRF and RPT assessed more than 3 years postoperatively were compared according to ages and time. Improvement of DRF and RPT was also compared. The relationship between the improvement in DRF in the first six months and renal function assessed in 3-year was also analyzed. The results showed that the renal function of functional obstruction was significantly lower than other groups (p＜0.0001). GH patients who underwent pyeloplasty before 36 months of age (n = 12) experienced more improvement in DRF compared with GH patients who underwent surgery after 36 months of age (n = 21) (p＜0.0001). DRF measured in the first six postoperative months was significantly higher than other groups (n = 12) (p＜0.0001). There is a positive positive correlation between DRF in the first six months and renal function assessed in 3-y (r =0.8193). In conclusion, it is worthwhile to preserve the kidney in children with GH. Functional obstruction should be independent from UPJO and surgical treatment is inadvisable. The rate of improvement in DRF in the first six months is a good indicator to outcome.