Journal of Clinical and Experimental Medical Research

3

Authors: Pobedenniy A. L.

The content of main pro- and anti-inflammatory cytokine in serum of the patients with traumatic brain injury immediately after surgical operation and 10 days later was studied in the article. Concentrations of IL-1β, IL-2, IL-6 were increased significantly without elevation of IL-4 and γ-IFN. Ratio IL-1β/IL-4 was increased too. After 10 days of usual therapy we observed absence of their dynamics. It was a basis for the immunocorection.

4

Authors: Khyzhnyak M. V., Potapov O. O., Bodnarchuk Y. A.

Uncomplicated fractures of the thoracolumbar region are widespread pathology. These kinds of spine injuries represent over half all spine fractures. There are modern classifications of spine injuries and their biomechanical structure. The three column classification of Denis was developed to show the injury mechanism and its further treatment. Patients mostly complain of severe local back pain and radiculopathy. Results of puncture percutaneous vertebroplasty (PPVP) method in surgery were given. Under the experiment were 55 patients in their 51+1.2 years suffered traumatic compressive fractures of vertebral bodies. We have operated 55 patients. Pain syndrome strength was evaluated with Visual Analogue Scale. Such positive postoperative dynamics as pain syndrome regress and patient’s quality of live improvement were noticed. Thus, PPVP is considered to be minimally invasive and extremely effective method of traumatic compressive vertebral bodies’ fractures treatment.

5

Authors: Potselyev V. I.

The article is based on decadelong monitoring of 123 general-family practice institutions located in the rural area. It was pointed that medical care quality improving caused by: diagnostic equipment completeness, certain day patient facilities number and capacity enlarging, geographically-territorial accessibility reforming, normalization of population general number regarding to the certain institution. Obtained data dealt with significant changes caused by geographically-territorial accessibility, ambulatory completeness of a general practitioner and the new qualimetry approach usage. Thus, the approach can be involved into similar analyzes, Health Care System quality monitoring and managerial decision evaluation of effectiveness.

5

Authors: Lukavenko I. M., Andrjushenko V. V., Kononenko M. G., Yazykov O. V

We studied 10 samples of histological material (mammary gland tissue) from 6 women with precancerous breast pathology. The levels of estrogen, progesterone, mammaglobin receptor's expression were defined. The same histological structure appeared nonhomogeneous according to immunogistochemical test-results. This may be representative the characteristics of the hormonal status and the age of patients, and also be a manifestation of breast cancer and an indicator of a predisposition to it.

5

Authors: Kutya S. A., Schvets T. A., Melnik M. V.

Article is about anatomists, who were papal physicians: M.R. Colombo (c.1515-1559),G.B. Canano (1515-1579), G.C. Aranzi (1530-1589), C. Varolio (1543-1575), A. Cesalpino (1525- 1603), M. Malpighi (1628-1694), G.M. Lancisi (1654-1720) and G. Flaiani (1739-1808). Their contribution into anatomy and brief biographical information are given.

6

Authors: Gafarova Ye. A., Pikalyuk V. S., Kryventsov М. А

The article deals with the liver structural changes of experimental rodents of juvenile age, who were under 10- or 30-times hypergravitation influence. These changes mostly have reversible character and are accompanied by adaptive-compensative mechanism activization. They are directed to reduce negative influence of exogenic factors. Both structural-functional changes and adaptive reaction intensivety dominate in the rodent subgroup, which got more influence. Obtained gysto- and cytomorphological data prove positive adaptive response establishment on cellular level. First of all this positive adaptive response is characterized by cell quantity increasing of different mitosis stages. Most obvious histopathological changes were found in the mature rodent subgroup, which are characterized by cytomorphological traits of the vacuolar degeneration and non-adequate adaptive response realization. However, more obvious negative influence of the overload was pointed in the longer term experiment (30-times hypergravitation influence)

6

Authors: Kryvoshey A. V.

The aim of the article is devoted to study microcirculation flow disorder and peripheral hemodynamics in children, who have responsive arthropathia. There were given data concerning peculiarities and correlations between microcirculation and peripheral hemodynamics under responsive arthropathia in children. Microcirculation functional changes were pointed out. These changes dealt with influence on both flow distribution components and exchanging, draining components. It was pointed that hemodynamics disorders in proximal area of the hurt joint had compensatory character, while the distal area obtained decompensatory character. There was direct correlation among responsive arthropathia disease severity, ill person age, microcirculation flow disorder level and peripheral hemodynamics. Thus, disease severity worsening and age increasing leaded to severity of microcirculation and hemodynamics disorders.

6

Authors: Ospanova T. S., Zaozerska N. V.

The scope of the article was to study expression of adhesion molecules and screen respiratory functions in the patients with diabetic nephropathy of different chronic renal disease progression. Interaction between on the one hand: E-Selectine molecule levels, sICAM, sVCAM and MAU, proteinuria of first-state chronic renal disease, and on the other hand respiratory functions and creatinine of third-state chronic renal disease. Obtained data will be useful for early prognosis of renal irritation and pulmonary affection signs of diabetes mellitus.

8

Authors: Bessalova Ye. Yu., Pikalyuk V. S., Korolev V. A

The article is devoted to study biological effects of cerebrospinal fluid of lactate cows with its injection into female and male white rats as a xenogenic medicine. We studied the reproductive systems by physiological and morphological methods. We pointed significant, but reversible inhibitory effect of cerebrospinal fluid derived during physiological anovulation of a donor, we analyzed this effect of the recipient’s reproductive system. Inhibitory effect of cerebrospinal fluid on gonad was identified both in male and female organisms. This effect is reversible and dependable on recipient’s age and cerebrospinal fluid frequency of administration. Thus, the peak changes were observed during cerebrospinal fluid injection in perinatal period and numerous injections. There were the following changes: mating number and sexual motivation reducing; dynamic of estrous cycle and phases of cycle duration; female’s fertility decrease and temporary male infertility; testicles and ovary weight reductions, reproductive hormones level in blood serum, anovulation was caused by artresia of tertiary follicles and structural changes of target-organs for ovarian hormones. The article has validated the hypothesis about absence of cerebrospinal fluid immunogenetic disparity of different mammal species and hypothesis about its contraceptive effect on derived samples during the donor’s physiological anovulation. We preserved normal characteristics of cerebrospinal fluid by intravital derivation, cryoconservation and we did not do filtration. Thus, we studied injected fluid as biological media and the biogenic medicine.