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Evaluation of Hepatotoxicity of Lanthanide Complexes of Fish Catla catla
Authors: Meshram Nitin P | Janbandhu Kishor S
Number of views: 333
A series of rare earth complexes are being used for various medical uses particularly in the tumorology, immunoresonance transfer mechanisms, diagnosis of mutation and probing of Molecular interactions. Most of workers discussed the biodistributiion and dosimetry for therapy planning of specific tumors related to stomatostatin receptor. Chelating complexes of various lanthanide series interact with biological tissue matter differently and may show highly specific responses with respect to tissue atrophy, tissue modification, antihaemolytic and even prevention of intravenous blood clotting.
Terbium chelates have been selectively used in sensitized emission immunoresonance energy transfer (SEIRET) method, which can detect the association of molecules of Duchenne muscular dystrophy gene. Europium (III) has been successfully used as typical biomarkers because of their selective uptake and binding.
The exposure of fishes to low doses of La and Nd complexes provided significant information about the low hepatotoxicity of such complexes. Increased levels of SGPT are indicative of hepatitis, obstructive Jaundice, Metastatic carcinoma, hepatic cojestion and myocardial infarction. So that measurement of SGPT usually reflects liver status.