Current Research in Pharmaceutical Sciences

Number 7 (1), 2017

01-10
Plasticizers: A Vital Excipient in Novel Pharmaceutical Formulations

Authors: Ashwani Mishra, A K Pathak

Abstract

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Number of views: 2066

Plasticizers have got significant role in pharmaceutical formulations because of their vital importance in the formulations like gastro-retentive films, ocular films, transdermal films, buccal films, oro-dispersible films. Flexibility, Endurance, Resistibility and Stability which are suitable properties of formulation could be easily achieved by using plasticizers which ultimately imparted desired characteristic in the formulation by the radical use of this excipient. In this review an effort was made to disclose importance, theories and plasticizers mechanism in different novel pharmaceutical formulations to understand its versatility efficiency, utility and tendency to modified different novel pharmaceutical formulations.

11-15
Review on Pharmacology and Phytochemistry of Cyperus rotundus L.

Authors: Muneesh Kumar, Manisha Rani, Bibekananda Meher

Abstract

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Number of views: 972

Nowadays there is increasing interest of researchers to explore herbal drugs for health benefits of human as well as animals. Drugs which are obtained from natural sources are pharmacologically potent and have low or no side effects for use in preventive medicine.Cyperusrotundus L. is commonly known as nagarmotha, motha in local languages.It is available all over the country. Cyperusrotundus is having some reported activities like antidiabetic, hypolipidemic, hepatoprotective and antimicrobial properties. It contains flavonoids, tannins, glycosides, monoterpenes, sesquiterpenes, sitosterol, alkaloids saponins, terpenoids, essential oils, starch, carbohydrates, protein, separated amino acids and different secondary metabolites. Considering the growing interest in the field of plant drugs assessing different pharmacological activities. In this review we are discussing about the therapeutic potential and chemical constituents of Cyperusrotundus.

16-24
QSAR Modeling for Relative Toxicity Prediction of (3-(2-chloroquinolin-3-yl)oxiran-2-yl)(phenyl) methanone Derivatives

Authors: Amit Kumar Tiwari, Preveena Narasimhamurthy, Gopalpur Nagendrappa, Abhilash Thakur

Abstract

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Number of views: 417

2-Chloroquinoline-3-carbaldehyde and its substituted products are extremely versatile intermediates for synthesizing a variety of compounds containing quinoline moiety, which find many pharmaceutical and other applications. Quantitative structure-activity relationship (QSAR) plays an important role in toxicity prediction. The present study deals with acute toxicity predictions LD50 (medianlethal dose) values of (3-(2-chloroquinolin-3-yl)oxiran-2-yl)(phenyl) methanone and its derivatives in rat by oral exposure through QSAR modelling software package T.E.S.T. In the present study the toxicity (LD50) is evaluated using a variety of QSAR methodologies, such as hierarchical clustering, the Food and Drug Administration (FDA) MDL, nearest neighbor and a consensus model. For compounds No. 1 to 4, 7, 10 and 11 hierarchical clustering method does not provide the LD50 values; however, other methods have successfully provided the toxicity estimation for the same. The said software helps to predict the exact LD50 values when compared to experimental data reported in the range (>2000 to >5000 mg/kg). This is a preliminary observation from screening of LD50 values using the said software package. Further study may be relevant using other software to compare the predicted data.

25-29
Development and in vitro Evaluation of Floating Microparticles of Cimetidine

Authors: Nidhi Jain, Rahul Gupta

Abstract

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Number of views: 426

Microspheres of Cimetidine by emulsion solvent diffusion technique were prepared for sustained delivery by using polymers like Ethyl cellulose and Carbopol 934in order to extend the drug release for about 12 h in the upper GIT, which may result in enhanced absorption and there by improved bioavailability. The particle size was determined by optical micrometer and average particle size was found to be in range of89.5± 2.63 to 124.33± 2.14. Formulation F2 containing Ethyl cellulose and Carbopol 934 polymer blend showed the best floating ability (97.5%) as compared with other formulations. From Scanning Electron Microscopy (SEM) it was observed that, Microparticles were found to be spherical in shape with smooth surface texture with a hollow space within. Among all formulations, F2 showed appropriate balance between buoyancy and drug release rate of 88.65% in 12 h, which was considered as the best formulation.

30-32
A Market Survey of Amlodipine (Antihypertensive) in Moradabad City

Authors: Samreen Jahan, Jagdish K Sahu

Abstract

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Number of views: 419

A market survey of Amlodipine (Antihypertensive drug) was conducted at several medical shops in Moradabad City. The various brands of Amlodipine are Citanil-T, Amlokind, Omletime, Amodep, Angicam, Lupidip, Amlogen,Amlip etc. are available in selected areas. The Amlokind is more prescribed by doctors. The highest selling brand of Amlodipine is Amlokind. According to medical survey it has been shown that Amlokind (Mankind Pharmaceuticals Pvt Ltd.) is highest selling brand in Moradabad city. Amlodipine is good Antihypertensive drug.