Current Research in Pharmaceutical Sciences

77-83

Authors: Priyanka Gupta and Vikas Jharia

Moringa oleifera Lam [Moringaceae] is a highly valued plant, distributed in many countries of the tropics and subtropics. It has an impressive range of medicinal uses with high nutritional value. It is known by such regional names as drumstick tree, Sajiwan, kelor, Murungai kaai, marango, mulangay, saijhan, and sajna. Different parts of this plant such as the leaves, roots, seed, bark, fruit, flowers and immature pods contain a profile of important minerals, and are a good source of protein, vitamins, β -carotene, aminoacids and various phenolics which act as cardiac and circulatory stimulants, possess anitumor, antipyretic, antiepileptic, antiinflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol lowering, antioxidant, antidiabetic, hepatoprotective, antibacterial and antifungal activities, and are being employed for the treatment of different ailments in the indigenous system of medicine. This plant have broad spectrum activities so, further studies on other models and extensive clinical trials are needed to confirm these findings. The present study was undertaken to screen various phytochemicals like flavonoids and terpenoids present in the stem bark and evaluate the potentials for use of this plant, which will help to formulate effective herbal preparation that will be used to combat various disorders.

87-91

Authors: Rajendra Chauhan, Priyanka Arjariya, Gurdeep Singh, Naveen Sharma, Ashish Mangal

The main objective of the present study is to develop a single unit gastric floating drug delivery system (GFDDS) of Cefpodoxime Proxet.Tablets were prepared using various proportions of polymers such as HPMCK4M and Eudragit RS 100. Direct compression method was used for the preparation of tablets. Five different formulations were developed. Tablets were evaluated for physical characterization viz. weight variation, thickness, hardness, friability, drug content, swelling index, buoyancy determination, and in vitro drug release study. All parameters complied with IP limits. Formulation with both the polymers (F5) showed sustained release. Formulations with hydrophilic polymer (F1, F2) showed high release of drug when compared to formulations with hydrophobic polymers (F3, F4). Polymer HPMCK4M and the combination of Eudragit RS100 were found to have optimum floating characters for a longer period. It may be concluded from whole study that the combinations of hydrophilic polymers with hydrophobic polymers are suitable to optimize sustained release formulation of Cefpodoxime Proxetil.