Current Research in Pharmaceutical Sciences

45-47

Authors: Piyush Gupta, Ashish Kumar Parashar and Rajesh Kumar Nema

Solanum xanthocarpum (Solanaceae) is distributed all over India and has been used by triable as well a local people widely. Locally it is known as “Kantakari”. In present investigation the aim is to focus on the anthelmintic activity of this valuable medicinal plant Solanum xanthocarpum. Helminthiasis is a worldwide and one of the common diseases of all ages. As per WHO more than two billion people harbor this infection. From the survey of WHO only few drugs are frequently used in the treatment of helminthes in human, due to the cost and the development of resistance against these drugs. In the present work the alcoholic and aqueous extracts of Solanum xanthocarpum were evaluated for its anthelmintic activity against adult earthworms (Phertima prosthuma). The activities of the extracts were compared with standard Albendazole. Both the extracts and standard were prepared in saline water. The alcoholic and aqueous extract showed significant anthelmintic activity and it was found that the aqueous extract activity is higher than alcoholic extract.

53-57

Authors: Sunil Sangare, Nidhi Jain, A K Pathak

The purpose of this project work to develop a antibacterial patch that may stick to the wounds, providing protection against bacterial infection without disturbing the healthy tissues present around the wound. As there is no external agent that can heal the wound, as body has its own wound healing mechanism, only thing that can be done is protecting the wounds against bacteria so healing can be fast. Here is film is prepared using neomycin antibacterial agent and using polymer gelatin that too has anti bacterial effect. The neomycin patch will be biocompatible material without given any side effect to the applied natural systems. The incorporation of PEG with gelatin has the aim of developing a material that would have good mechanical strength, be thermally stable on human body, and have good swelling property and effective water absorption capacity. The prepared will enhance both the rapidity of healing including reducing infection, pain, and scarring. An improved dressing also will reduce cost by improving the rate of wound healing and shorter the duration the treatment.

61-67

Authors: Pradeep K Sharma, Yogendra Mavai, Suman Jain

Medicinal plants have been used in various traditional systems, as they have potential against numerous diseases like cardiovascular disease. Currently, more than 200 clinically useful prescription drugs are derived from plants. Most of these were developed because of their use in traditional medicine. In several ancient systems of medicine including Ayurveda, Siddha and Unani, Achyranthus aspera & Murraya koenigii, two medicinally important herb from mainly Asian origin has vast number of therapeutic applications including hypolipidemic activity but very little information is available about their safety profile. It is a common believe that herbal products are safe because of which nobody care for the evaluation of their final preparation. We strongly recommend performing safety studies for the herbal preparations because all the extracts used are chemical in nature and there is strong possibility that these chemicals may react with each other and form some toxic compound or interact with the biomolecules. Keeping these things in mind, the present study has been envisaged and it was observed that water and chloroform extracts of Achyranthus aspera & Murraya koenigii are safe, based on the acute toxicity studies, as no abnormal changes are observed in treated animals. The combinations of both the extracts in 1:1 ratio are also safe and can be encapsulated into hard gelatin capsule of 000 size for human use.