Current Research in Pharmaceutical Sciences

8-14

Authors: Ankita Jain, A K Parashar, R K Nema, T Narsinghani

HPTLC is a most versatile technique and is known for uniformity, purity profile, assay values and precision and accuracy of results. It can handle several samples of even divergent nature and composition. HPTLC is a modern analytical separation method with extensive versatility, although already much utilized, is still with great potential for future development in research and development. It is accepted as a time-saving and most economical machine practically with minimum trouble shootings. It speeds up analysis work which is usually not possible with other parallel chromatographic techniques available. The scope of hyphenation of HPTLC with other analytical techniques appears to hold considerable promise for the analysts who previously have had reservation towards the use of planar chromatography. Its hyphenation with mass/infra red/laser spectroscopy, etc. opens a new dimension which makes it the most prestigious among the analytical chemists in the present perspective. In this article, we present a practical view of the concepts of various parameters in the validation fields of quantitative high-performance thin layer chromatography analytical methods in pharmaceutical analysis, as well as several recent methods to serve as an introduction to applications of analytical validation, whether they are for an academic or an industrial researcher.

21-28

Authors: Asheesh Singh,Vinayaditya Singh, Jagrati Singh, Naveen Sharma

Trovafloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class and is used to treat severe or life-threatening bacterial infections or bacterial infections that have failed to respond to other antibiotic classes. It is sold under various brand names, such as Trovan and Tavanic, the most common. Trovafloxacin is considered to be same as Ofloxacin by the U.S. Food and Drug Administration (FDA), with the exception of the potency shown in vitro against mycobacteria. In vitro, it is, in general, twice as potent as ofloxacin, whereas d-ofloxacin is less active against mycobacteria. The advantage of administering a single dose of a drug that is released over an extended period of time instead of numerous doses is now a day’s area of interest for formulation scientists in Pharmaceutical industry. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased safety margin of potent drug, reduction of fluctuation in steady-state drug levels, reduction in healthcare costs through improved therapy and shorter treatment period. Wide varieties of polymers like Hydroxy Propyl Methyl Cellulose (HPMC), Carboxy Methyl Cellulose (CMC), Ethyl Cellulose (EC), Cellulose Acetate Phthalate, HPMC K100M, Xanthan gum, Carrageenan gum, Karaya gum, HPMC K15, Carbopol 971P and Carbopol 974P etc. are available for retarding the release rate of drugs hence sustains the action of drugs.