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Synthesis and Antimicrobial screening of some Novel Substituted Thiophenes
Authors: Mohammad Asif Iqbal C , Satyendra D*,Apurba T , Patel M, Monika K, GirishK , Mohan S , Saravanan J
Number of views: 355
Plan: To synthesize some novel2-amino thiophenes with various substitutions at the 2-amino position for antibacterial and antifungal activity.
Prolog: Thiophenes containing organic compounds forms a significant group of drugs which exhibit an array of biological activities like anti-inflammatory, antibacterial, antifungal, anti-neoplastic, antiarthritic etc. Thus a series of new thiophenes havesynthesized with various substituents at 2-amino position and screened forantimicrobial activity.
Methodology: The parent compound 2-amino-3-(N-furfuryl amido)-4, 5-dimethyl thiophene was synthesized by condensing butan-2-one with furfuryl cyano acetamide in presence of sulphur and diethylamine. It was then derivatized to various Schiff bases by reacting with various substituted aromatic aldehydes. The synthesized new compounds were characterized by MP, TLC, IR, NMR and Mass spectra and were screened for their antibacterial and antifungal activity by using Ampicillin and Miconazolenitrate as standard respectively.
Outcome: The compounds MAI-2e, MAI-2k, & MAI-2l showed potent antibacterialand MAI-2a, MAI-2c, MAI-2e, & MAI-2fshowed potent antifungal activity.