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AN UPDATE ON CLINICAL APPLICATIONS OF NANOPARTICLES IN BRAIN AND RETINAL DISEASE (CNS)
Authors: Seyed Mehdi Aberoumandi, Rovshan Khalilov, Soodabeh Davaran, Aygun Nasibova, Elham Abbasi, Siamak Saghfi, Abolfazl Akbarzadeh
Number of views: 490
Malignant tumors are one of the highest frequently studied target diseases of nanotherapeutics amongst brain diseases. Chiefly, various pathological mechanisms as well as reactive oxygen species (ROS), biological actions of growth factors, and signaling pathways of proliferative potentials could be addressed with nanoparticle-based therapeutics. Nanoparticles have numerous benefits as therapeutic materials used for many human diseases as well as brain and retinal diseases. These nanomaterials through themselves exert therapeutic activities. Cerium oxide nanoparticles (nanoceria) are recognized to induce anti-inflammatory effects. Nanoneuromedicines are being established to growth drug penetration into locations of active microbial infection while preventive systemic toxicities. Adjunctive therapies are often used in combination with antimicrobials to diminish the inflammatory proceedings that contribute to CNS destruction and long-term damages associated by way of CNS infectious diseases; though, the greatoccurrence of adverse side effects with corticosteroids limits their usage.