International Journal of Pharmaceutical Sciences and Drug Research

230-235

Authors: N. G. Raghavendra Rao1*, Mahesh Kumar2, Mettu Srikanth Reddy1, C. Kistayya1, B. Mahipal Reddy1

Fosinopril is an antihypertensive, angiotensin converting enzyme inhibitor. This is used in the treatment of various cardiovascular disorders such as heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients and hypertension. In present research work an attempt has been made to prepare fast dissolving tablets of Fosinopril with increased rate of dissolution may leads to increase bioavailability. The fast dissolving tablets of Fosinopril were prepared by using sublimation method. Croscarmellose sodium is used as a superdisintegrant. Camphor, Urea and Menthol are used as a sublimating agent. The prepared tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, water absorption ratio, wetting time, in-vitro drug release, FTIR, DSC studies and short term stability studies. IR spectral analysis and DSC study showed that there was no drug interaction with formulation additives of the tablet. The blend was examined for the pre-compressional parameters. The prepared tablets formulations were evaluated for post-compressional parameters. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. The disintegration time of 17 to 52 sec, water absorption ratio of 50.75 to 84.41%, wetting time of 23.41 to 36.61sec. In-vitro dissolution studies on the promising formulations SF3, SF6 and SF9 formulations were carried out in 6.8 phosphate buffer solution. This data reveals that overall, the formulation SF3, SF6 and SF9 shows nearly faster drug release. The formulations SF3, SF6 and SF9 50 % of drug released in 0.67 min, 0.73min, and 0.69 min, respectively, and 90 % of drug released in 2.93 min, 4.88 min, and 3.83 min, respectively when compared to other tablet formulation. Among all the formulation SF3 were found to be promising and showed a disintegration time of 17 sec, 50 % of drug released in 0.67 min, and 90 % of drug released in 2.93 min. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. The results concluded that fast dissolving tablets Fosinopril showing enhanced dissolution, will lead to improved bioavailability, improved effectiveness and hence better patient compliance.

240-244

Authors: A. R. Chabukswar*, M. N. Mohokar, V. P. Choudhari, S. N. Sharma, S. D. Tambe, B. D. Pagare

Two simple, economical, precise and accurate methods are described for the simultaneous determination of Metoprolol Succinate (METO) and Amlodipine (AMLO) in combined tablet dosage form. The first method (Method A) is Absorption Corrected Method and second method (Method B) is Isoabsorptive Point Method. The absorbances at 277.017 nm and 235.62 nm in the Absorption Corrected Method and Isoabsorptive Point Method were selected to determine METO and AMLO, respectively in combined formulation. The methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization (ICH). All validation parameters were within the acceptable range. Under experimental conditions described, calibration curve, assay of tablets and recovery studies were performed. A critical evaluation of proposed methods were performed by statistical analysis of data where slope, intercept, correlation coefficient is shown in Table (1). As per the ICH guidelines, the method validation parameters checked. Beer’s law is obeyed in the concentration range of 50-250μg/ml and 5-25μg/ml for Metoprolol succinate and Amlodipine by both the methods.

250-252

Authors: Sreenu Thalla*, Jyothibasu Tammu, N. Delhiraj, K.Suresh Kumar

The present investigation was carried out to study the hypoglycemic effects of the hydro-alcoholic (70:30) extract of Calycopteris floribunda, in normal and streptozotocin induced diabetic model. Calycopteris floribunda, are reported to have medicinal and traditional values including hypoglycemic properties. Decreased blood glucose level of the test animals shows that the extract exhibit significant hypoglycemic activity when compared to diabetic control group, effect of various doses (100, 200 mg/kg, p.o) extract was studied on streptozotocin induced both diabetic and non diabetic rats. The results also indicated the dose dependent effect. The hypoglycemic activity produced by the extract may be due to increased uptake of glucose at the tissue level or by an increase in pancreatic beta cell function or due to inhibition of intestinal absorption of glucose. The present study supports the use of this herbal drug as hypoglycemic. The reduction in the glucose level in induced diabetic rats proved that Calycopteris floribunda having the hypoglycemic activity.