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Value of α-fetoprotein, β-HCG, inhibin A, and UE3 at second trimester for early screening of preeclampsia
Authors: Farah Farzaneh, Mohaddeseh Sharifi, Nasim Nourinasab, Sarang Younesi
Number of views: 255
Objective: To study the value of α-fetoprotein (α-FP),β-human chorionic gonadotropin
(β-HCG), inhibin A, and uncojugated estriol (UE3) at the second trimester for early
screening of preeclampsia. Methods: This cohort study was performed on 1 713 consecutive
pregnant women with gestational age from 15 to 18 weeks. We measured the serum levels
of α-FP, β-HCG, inhibin A, and UE3 and they were followed-up for 48 h after delivery.
Results: A total of 1 713 women were recruited and through the study 151 women (8.8%)
were diagnosed with preeclampsia (n=123, 21.5% in the pregnant women with high risk,
n=28, 2.5% in the pregnant women with low risk; P<0.000 1). The area under receiver
operating characteristic curve was estimated to be 2.39 MOM for α-FP, 2.84 MOM for
β-HCG, 1.92 MOM for inhibin A, and 0.77 MOM for UE3. The best cutoff value was
specifically considered for each marker that was determined a positive predictive value
ranged 19.60% for α-FP, 17.62% for β-HCG, 18.33% for inhibin A and 14.88% for UE3, a
negative predictive value ranged 95.63% for α-FP, 93.89% for β-HCG, 94.28% for inhibin
A and 93.57% for UE3, and an area under receiver operating characteristic curve ranged 0.70
for α-FP, 0.63 for β-HCG, 0.65 for inhibin A and 0.61 for UE3. Conclusions: This study
reveals that the new cutoff values are more valuable in screening preeclampsia. Although
these markers have a low positive predictive value, they present a high negative predictive
value. Also, the combination of α-FP,β-HCG and inhibin A and the combination of α-FP
and inhibin A have the highest value in screening preeclampsia.