Brahmi Extract Attenuated Spatial Learning and Memory Impairment and Cell Death of Rat Hippocampal CA1 Neurons after the 2-VO Induced Chronic Cerebral Hypoperfusion
Authors: Sarayut Vattananupon, Pranee Chadvongvan, Pravit Akarasereenont, M.D., Ph.D., Sompol Tapechum, M.D., Ph.D., Kanokwan Tilokskulchai, B.Sc.(Pharm.), Ph.D., Narawut Pakaprot, M.D., Ph.D.
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Background: Vascular dementia, a learning and memory af icted disease, is caused by chronic cerebral hypoperfusion which leads to neuronal injury and death. Brahmi extract is used in Indian Ayurvedic medicine to enhance learning and memory and to promote brain functions.
Objective: To examine the therapeutic potential of Brahmi extract as an alternative treatment for vascular dementia in the rat model of chronic cerebral hypoperfusion.
Methods: The chronic cerebral hypoperfusion was induced by permanent bilateral common carotid artery occlusion (2-VO), causing vascular dementia. After the occlusion, Brahmi extract was given for 2 months, and the spatial learning and memory tests were then performed after 2 months of drug administration. At the end, all animals were sacri ced, and the brains were removed for histological examination and counting of the hippocampal CA1 neurons.
Results: The 2-VO induced cerebral hypoperfusion reduced the hippocampal CA1 neuron count and impaired the spatial learning and memory. Brahmi extract, on the other hand, could attenuate the memory de cit and neuronal reduction. Conclusion: Brahmi extract attenuated the de cit induced by the permanent bilateral common carotid artery occlusion, suggesting the neuroprotective effects of Brahmi extract against the cerebral hypoperfusion.