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The red cell distribution width to platelet ratio predicts 30-day mortality of acute pulmonary embolism patients
Authors: Meliha Findik, Cemil Kavalci, Afsin Emre Kayipmaz, Murat Muratoglu, Elif Kilicli
Number of views: 331
Objective: To specify the clinical and sociodemographic characteristics, risk factors, factors
affecting mortality including hematologic parameters, and red blood cell distribution width
to platelet ratio (RPR) in patients with pulmonary thromboembolism, and to reduce the
mortality. Methods: The archive records of patients diagnosed with pulmonary embolism were
retrospectively examined. The histories, risk factors, physical examination findings, arterial
blood gas analysis, X-rays, laboratory, and computed tomography reports of all cases were
obtained via the hospital information system. Logistic regression analysis was performed to
determine the independent variables affecting early mortality. Results: A total of 146 patients
with a definitive diagnosis of pulmonary thromboembolism were included. Thirteen point
seven percent (n=20) of the deceased patients died at early term. Ninety percent of patients with
early mortality was 65 years or older. There were significantly differences in age, RPR, D-dimer,
creatinine, lymphocyte, pH, and body temperature between patients with and without early
mortality (P=0.017, P<0.001, P=0.019, P=0.025, P=0.042, P=0.013, P=0.017, respectively).
Logistic regression analysis showed that RPR was a statistically significant and independent
risk factors of mortality [P=0.026, OR: 0.254., 95% CI (0.326-5.056)]. In addition, there was
a significant difference in pulmonary embolism severity index classification between patients
with and without early mortality(P<0.034). Conclusions: RPR is an independent risk factor
of mortality of pulmonary embolism patients and may help emergency physician to stratify
mortality risks of pulmonary embolism patients.