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Curative effect of surgery combined with nerve growth factor preparation treatment of acute cerebral hemorrhage
Authors: Fei Luo
Number of views: 445
Objective: To study the effect of surgery combined with nerve growth factor preparation
treatment of acute cerebral hemorrhage on nerve cytokines and nerve injury.
Methods: 68 patients with acute cerebral hemorrhage who received emergency minimally
invasive evacuation of hematoma in Zigong No. 4 People’s Hospital between August 2014 and
September 2016 were selected and randomly divided into mNGF group and control group,
mNGF group received postoperative mouse nerve growth factor preparation combined with
conventional therapy, and control group accepted routine postoperative treatment. 10d, 20d
and 30d after treatment, the serum was collected to determine the levels of nerve cytokines and
nerve injury molecules.
Results: 10d, 20d and 30d after treatment, serum BDNF (5.29±0.88 vs. 3.58±0.61, 6.94±0.93
vs. 3.78±0.55, 9.28±1.13 vs. 4.57±0.62 ng/ml), NTF-α (2.94±0.52 vs. 1.35±0.18, 3.88±0.58
vs. 1.51±0.20, 5.21±0.72 vs. 2.95±0.46 ng/ml), NGF (0.89±0.11 vs. 0.62±0.08, 1.02±0.15
vs. 0.78±0.09, 1.45±0.18 vs. 0.92±0.12 ng/ml) and VEGF (147.53±19.52 vs. 110.38±14.28,
184.95±22.51 vs. 121.29±17.85, 237.49±31.28 vs. 145.38±18.31 pg/ml) levels of mNGF
group were significantly higher than those of control group while S100β (1.27±0.20 vs.
2.19±0.33, 0.94±0.14 vs. 1.76±0.25, 0.71±0.09 vs. 1.32±0.17 ng/ml), GFAP (2.08±0.36 vs.
4.42±0.55, 1.65±0.25 vs. 3.57±0.51, 1.31±0.17 vs. 2.93±0.42 pg/ml), NSE (34.21±5.82 vs.
73.19±9.35, 27.58±4.12 vs. 58.76±8.28, 22.12±3.25 vs. 39.52±5.28 ng/ml), MBP (5.28±0.93
vs. 11.28±1.86, 3.89±0.51 vs. 9.12±1.14, 3.12±0.41 vs. 6.79±0.94 ng/ml), MDA (6.97±0.93 vs.
14.21±1.87, 5.02±0.78 vs. 11.75±1.76, 3.57±0.62 vs. 8.12±0.99 μmol/L), AOPP(65.19±9.68
vs. 155.62±19.63, 48.59±7.21 vs. 118.75±16.85, 37.83±5.28 vs. 82.11±10.18 μmol/L) and
8-OHdG (4.77±0.67 vs. 10.28±1.52, 3.52±0.51 vs. 9.38±1.15, 2.33±0.41 vs. 6.52±0.92 ng/ml)
levels were significantly lower than those of control group.
Conclusion: Surgery combined with nerve growth factor preparation treatment of acute
cerebral hemorrhage can improve neural nutritional status and reduce nerve injury degree, and
it is beneficial to the recovery of neural function.