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USING UV SPECTROPHOTOMETRIC METHOD TO DETERMINE THE LINEARITY OF VILDAGLIPTIN (VLD) BRANDS.
Authors: | Naveed S | Ashraf Z | and | Tanweer A.M |
Number of views: 1050
Background: Vildagliptin (VLD) is belonging to a new dipeptidyl peptidase-IV inhibitor class of drugs. VLD is an oral anti-diabetic drug (anti-hyperglycemic agent). The
IUPAC formula of vildagliptin is (2S)-1-[[(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl) amino]acetyl]-2-pyrrolidinecarbonitrile). Objectives: The purpose of this study was
to carry out the pharmaceutical assay on different brands (VILDOS, GALVIS and VILGLIP) of Vildagliptin, by Shimadzu double beam 1601 UV visible spectrophotometer
at wavelength 266nm. Methods: Five dilutions of 200ppm, 100, 50, 25, 12 ppm for each brand of Vildagliptin were prepared. Results: Results indications that
absorbance is directly proportion to concentration thus, it is obeys to Beers lambert law and assay of all brands of Validagliptin. We have performed these types of
assay for different brand which helpful for selecting drugs. Conclusion: It shows a linear relationship between absorbance and concentration.
KEYWORDS: Vildagliptin, dipeptidyl peptidase-IV inhibitor, anti-diabetic drug.