INTERNATIONAL JOURNAL OF ENDORSING HEALTH SCIENCE RESEARCH

1-4

Authors: Muhammad Bilal Siddiqui 1&2, Chiu Wan Ng 3, Wah Yun Low 4

The world has been unable to meet the United Nations Millennium Development Goals (MDGs) of reducing child mortality by 2015. Since 1990, there is an established disparity of under-5 mortality rates among countries across the globe. This disparity is due to high burden of child deaths in several of the low income countries. These high burden countries includes India, Nigeria, Pakistan and Democratic Republic of the Congo (DRoC) (UNICEF-Report-2015). Currently, these four countries carry almost 45% of the global burden of child deaths. If these high burden countries continues to shows such trends of child mortality, then in the next 15 years or so, they will be carrying almost half of the global burden of child mortality (UNIGCME-2015).

11-16

Authors: Muhammad Kashif1, Ali Yasir2, Amber Hakim1, Abdur Rasheed1&3.

DM is an established risk factor for congestive cardiac failure, in which the diastolic function is impaired. The majority of these patients may be asymptomatic without signs of overt heart failure. The aim of this study was to determine asymptomatic Left Ventricular Diastolic Dysfuction (LVDD) in Non-Insulin Dependent Diabetes Mellitus (NIDDM) in association with glycemic control and to assess the risk factors for the development of diastolic dysfunction. This cross sectional study was conducted at the Tabba Heart Institute, Karachi from Dec, 2011 to Nov 2012, 101 asymptomatic patients with type 2 diabetes without evidence of cardio-respiratory illness were enrolled. LVDD was evaluated by Doppler echocardiography, which included the valsalva manoeuvre. A total of 101 patients, LVDD was found in 67 subjects (66.34%) of whom 52 (51.48%) had impaired relaxation and 15 (14.85%) had a pseudonormal pattern of ventricular filling. The potential risk factors for the development of LVDD in type 2 diabetics were (a) age ≥45 years was associated with an almost three times higher risk for LVDD, (b) females had almost two times a higher risk of LVDD as compared with men, and (c) Diabetic patients of more than two years’ duration had a two times higher risk of LVDD. The study results also indicate that LVDD was significantly associated with increased age, longer duration of Diabetes and glycemic control (glycated HbA1c levels) and LVDD is found in diabetic patients before the onset of clinically detectable disease. The high prevalence of LVDD suggests that screening for LVDD should include procedures such as the valsalva manoeuvre.

17-21

Authors: Ali Abbas1, Raza Sayani2, Syed Muhammad Mustahsan1 & Anwar Saeed2

Introduction: Glanzmann’s thrombasthenia (GT) is a rare, genetically inherited, functional disorder of platelets. The pathology is deficient or dysfunctional platelet glycoprotein IIb/IIIa (GP IIb/IIIa) complex resulting in bleeding diathesis. Case Report: Here in, we report the effectivity of angioembolization with factor VII in a patient with Glanzmann’s thrombasthenia (GT), who presented with recurrent bleeding from duodenal ulcer. Conclusion: Angioembolization with added infusion of factor VII, can be considered an equally effective alternate to platelet transfusion in patients of GT, who present with recurrent bleeding.

27-31

Authors: Aisha Asad, Parisa Sanawar, Zurrya Fasih & Kulsoom Qutb.

Traumatic injury is one of the major health problems in our city due to its frequency, prevalence, costs and treatment. Traumatic injuries of sudden onset and severity may require immediate resuscitation and interventions. Serious traumatic injuries have the potential to cause prolonged disability or death. The aim of this paper is to review the frequency and types of injuries in different age groups. This paper provides a quick method to receive a primary understanding of common causes of traumatic injuries. To determine incidence, pattern and implication of injuries in different age groups. A cross sectional study was performed on a sample of 150 patients, within a period of 6 months (October 2014 – March 2015). It was taken through non probability purposive sampling, in orthopaedic surgery department of Jinnah Postgraduate Medical Centre, Karachi. An informed verbal consent was taken and pilot study was conducted to assess the validity of questionnaire. A structured questionnaire was filled; data was analysed by SPSS version 16. The study conducted on 150 people, contained 103 males (68.7%) and 47 females (31.3%). Injuries were common in middle age group (40 to 60 years). Most traumas occurred on road (61.3%). Majority of people were travelling at time of injury (54.7%). Major cause of injury was found to be transport accidents (48.7%). All the victims were not provided with first aid care in transportation. Severity at emergency room of patients was mainly moderate (52.7%). Majority of young adults suffered with hip dislocation and femur fracture (10.0%) while head injury was prevalent among (6.0%) of people. Incidence of traumatic injuries and accidents is increasing day by day. The study proved that Road traffic accident is the major cause of injury in traumatic patients. Ambulances and other emergency medical services need to upgrade their facilities during transportation. Strict laws should be made to wear seat belts/ helmets during travelling. Appropriate medical care facilities (including trauma centres) need to be established at district level, sub-divisional level to provide good and quality care to trauma patients.