International Journal of Ayurveda and Pharmaceutical Chemistry

4

Authors: Santosh Bashakar Somatkar and Kalpana S. Wakode

Ayurvedic approach for management of vartmasharkara and to treat symptoms and to prevent recurrence of disease. Vartmasharkara is one of the vartmagat netraroga which is characterized by irritation, Foreign body sensation, discomfort, occasional corneal abrasion. This condition can be correlated to concretions which are degenerative product of leucocytes to produce an epithelial inclusion cyst filled with epithelial cells and keratin debris. This is most common in old age group. Generally does not cause any permanent damage to eye sight. In Ayurveda treatment comprises of Lekhan and then saindhar shalkshna churna pratisaran. In present study Lekhannottar saindhav pratisaran is selected in the form of local therapy saindhav has property of chakshusha and help to avoid recurrence of disease. Hence selected for present study.

5

Authors: Neelam Choudhary

Masi Kalpana is a dosage form in Ayurveda Pharmaceutics where the drug is brought to a carbonized form by the process of employing heat to the dry ingredients of drug. The drugs selected for Masi preparation can be of plant or animal origin. It is used for both internal and external use. Acharya Sushruta described Masi Kalpana with respect to Vrana Chikitsa. In this article, we have prepared the Triphala Masi by using the closed method.

6

Authors: PoojaWankhade and A.B.Deshmukh

Pishtak is one of the shuklagata netraroga described by Ayurveda Acharyas in texts like Sushruta Samhita, Ashtang Hridaya etc. Pishtak can be compared to Pinguecula which is formation of yellowish white patch on bulbar conjunctiva near limbus. The disease is more common in outdoor workers and people living in hot climates.In modern science there is no specific treatment. Only lubricating drops are given which temporary give relief but recurrence occurs frequently. According to Ayurveda Pishtak is aushadhisadhyavyadhi. Acharya Sushruta described many Anjana Kalpas in Uttartantra for various eye diseases. Pathyadi Anjana Varti is one of them which is used to treat Kaphaja Vyadhi. Pishtak (Pinguecula) is also Kaphaja Vyadhi. The formulation Pathyadi Anjana contains drugs Pathya, Haridra, Yashtimadhu which all are Chakshushya. Pathyadi Anjana Varti is the lekhananjana. Hence the formulation Pathyadi Anjana is selected for clinical study from Sushrut Samhita

7

Authors: Priti Garg

Spontaneous pregnancy loss is a surprisingly common occurrence with approximately15% of all clinically recognized pregnancies resulting in pregnancy failure. Recurrent pregnancy loss (RPL) is defined as three or more consecutive spontaneous losses of pregnancy. Recurrent miscarriage is thought to have multiple etiologies, including parental chromosomal anomalies, maternal thrombophilic disorders, immune dysfunction and endocrine disturbances. This review highlights the current understanding of the various etiologies implicated in RPL, including role of Yastimadhu to prevent RPL.

7

Authors: C.S.Maladkar

The aim of this article is to view the role of processing techniques in the preparation of Bhasma. For any metal & minerals to be therapeutically effective, it is necessary that it should be prepared with caution. These metals have a different structure than the tissue constituents. If these are used in unprocessed form then they will not be metabolized, will get assimilated to the tissue cells of the body may produce harmful effects to the body. To prepare them as non-toxic, easily digestible, therapeutically potent and make them suitable for metabolic changes, several processing techniques have been mentioned. In this manuscript, significant information is provided on processing techniques of Bhasma.

7

Authors: Prachi N. Waghmare, E.E. Mojes and S. G. Topre

Ayurveda has describe Agni as an important factor of digestion and metabolism. Tridoshas are the important factors which help Agni to digest food along with other factors which take part in pachan kriya like aharparinamkarbhav, rasa , vipaka,etc. If the process of digestion is compared to that of cooking rice, the stomach like the vessel, receives food, vata provides the necessary condition like air blower, pitta acts like the stove providing optimum working condition, while kapha provides the moisture needed much like the water in the vessel. When all these factors are normal and well balanced, an optimum condition is created to digest the food completely. Variation of Agni due to tridoshas are of four types –sama, visham, teekshna and manda. Mandagni is associated with excess kapha. Mandagni affects the ahara pachan kriya leading to production of saama ahara rasa,which ultimately causes rasa dhatwagni mandya and uttarottar dhatu remains malnourished. Change in lifestyle responsible for change in food culture is making people more and more susceptible to diseases. Ayurveda texts mention Mandagni to be root cause of every disease.Hence, the study is taken to understand the concept of mandagni from sharir kriya point of view and its effect on ahara pachan kriya.

8

Authors: Rajpoot Ranjana

Ascites or Jalodar is the most common decompensating event in cirrhosis. The standard modern treatments generally provide provisional relief with time dependent reoccurrence of disease due to permanent damage of hepatic paryenchyme which may finally require liver transplantation. A 30 year old female patient approached with grade II ascites with bilateral pedal edema (++). She was subjected to treatment involving ayurvedic drugs in specific dosing pattern with restricted diet plan for one year. This case report demonstrated the successful treatment of grade II ascitis due to cryptogenic liver cirrhosis with hepatorenal syndrome.

8

Authors: Rupali Bawa, Chandurkar Nitin and Amar Kamble

This dissertation aimed at the comparative study of structural changes in Janusandhi i.e., Knee joint with special reference to Amvat and Sandhigatvat. These days joint pain is very common complaint of the patients all over the world creating great social health concern. Amavat and Sandhigatvat are the critical diseases from treatment as well as prognosis point of view5,6. The severity of pain is much more in these diseases due to continuous progressive degenerative changes. Ayurvedic science, the most ancient & trusted medicinal system, has explained Amvata and Sandhigatvat diseases with detailed and appropriate pathophysiology5,6. This study includes assessment of literary as well as clinical aspects of Amavata and Sandhigatvat diseases affecting significantly knee joint i.e., JanuSandhi.On the basis of clinical study of 30 patients each having Amavata and Sandhigatvat and the changes occurring in affected JanuSandhi the inferences are drawn. In Sandhigatvat maximum patients showed osteoporosis, osteophytes, loss of joint space whereas in Amvat maximum patients had muscle wasting.

8

Authors: Ujwala Ashokrao Jadhao, Sima Ashok Kurule, C. E. Lagad and D.S.Wadodkar

Rasashastra is the science of applied pharmaceutical procedures which is based on experimental studies. Nirmalikaran is one of the important processes of external purification of Rasadravyaswhich is specially mentioned in classical textbook of Rasashastra that is Rasataranginimainly for three dravyasKalmisora, Tankana, &Tutha. Nirmalikaranis based on the phenomenon of dissolution, filtration and evaporation with crystal formation. While doing this procedure of nirmalikaran as per text some problems were arises in solubility of dravyadue to proportion of water indicated. In Present study some modifications in the quantity of water to be added was done to attain complete solubility and filtration of drug which aimed to study the principles of nirmalikaran experimentally.

10

Authors: Archana Negi, Shweta Shukla, Deshraj Singh and Bhupinder Singh

Ulcerative colitis is one of the common Gastrointestinal (GIT) disorders encountered by clinicians in day-to-day life. It is a type of Inflammatory Bowel Disease (IBD) that usually involves the mucosa of rectum and extends proximally to involve all or part of the colon. A westernized environment and lifestyle is linked to the appearance of ulcerative colitis which is associated with smoking, unhealthy diet, medication use, stress etc. In Allopathic system of medicine drugs like 5 –Aminosalicylates, Glucocorticoids, anti-TNF therapy etc. are used for its treatment but they have many side effects like headache , nausea, vomiting ,hypersensitivity reactions due to Sulfasalazine ,osteoporosis due to use of Glucocorticoids etc. On the other hand Ayurveda is the Science of life in which Humoral balance is emphasized. Use of Deepana, Pachana drugs and Pichha Vasti is quite effective in this. Role of Pichha Vasti in Ulcerative colitis is discussed in detailed in the article.

11

Authors: S. N. V. Neeraja D and Paramkusha Rao M

Ayurveda is the oldest system of medicine. It gives importance to the women health care particularly when it comes to the Prenatal and Postnatal care. After delivery women have to follow certain dietetic rules and lifestyle modification changes, mentioned in the Sutika Paricharya which helps her to restore to the Pre-pregnant status. Postpartum weight retention in the retention of women after 6 weeks of delivery is influenced by many factors that include the Gestational weight gain, stress and postpartum depression, sleep intervals, hormonal changes, and adiposity changes. This condition may lead to obesity and other metabolic disorders in future with the changes in the lifestyle.

12

Authors: Dhiman Sonia, Kumar Ajay, Dhiman Monika, Chawla Kumar Satbir and Priyanka

Kumari (Aloe barbadensis Miller) is non controversial plant, but three types of (Musabbar) aloe are sold in market i.e. Barbados aloe, Socotrine aloe and Cape aloe which are prepared from Aloe barbadensis Miller, Aloe perryi Baker and Aloe ferox Miller respectively and other inferior aloe are also sold like Natal aloes by the name of Musabbar. These species of aloe are difficult to identify hence pharmacignostical study of Aloe barbadensis Miller was done. It is coarse looking, perennial succulent plant, grown close to the ground in a typical rosette shape, Strong, shallow and fibrous roots have arbuscular mycorrhiza. Leaves are crowded on the top of the stem with spiral orientation. Dark green leaves have glaucous spots, wider at the base tapering gradually to the pointed tip, concave above, convex beneath, serrated margins. Rind, sap, mucilage gel, inner gel is layers of leaves. Flowers are born in terminal racemes on the scape.Stalked, numerous having yellow tubular corolla with six stamens. Fruits are oblong, ovoid. The micrograph of the adaxial leaf epidermal layer exhibited the characteristic plasmolyzed cytoplasm, sunken stomata complex having two guard cells, tetracytic, hexagonal epidermal cells and some cells were small square shape. In contrast, the abaxial leaf epidermal layer was less plasmolyzed and cell walls were less thick. Epidermal tissue, chlorenchyma, aquiferous tissue, vascular bundle are four type of tissues present in leaves. The Tikta Rasa was observed as the predominant Rasa of Kumari Swarasa (70%). According to 50% volunteers both Katu and Tikta Rasa were present.

13

Authors: Pallavi Singh, Premraj Chaudhary and Rohit Ranjan

Cow is equated to mother in the Indian tradition and her urine is panacea of all diseases. Cow urine is the treasure of medicines used to cure a no. of diseases since ancient times. Various researches have also proved the significance of cow urine. In Ayurveda, cow urine is used alone and also in the yogas to alleviate various health issues. In this article an attempt has been made to compile the use of cow urine in Brahattrayi to facilitate its literary research which will serve as a base for further scientific researches.

14

Authors: Shital Kolpekwar and Pradipkumar R Suryawanshi

Introduction: Grahani is very common disease in society. In present era factors like stressful life, faulty and irregular habit of food intake, lack of time for food intake and deification result in dysfunction of digestive system. It becomes weak causing Garahani roga; Pravahika, Visuchika, Aalsaka which are similar to Irritable bowel syndrome, inflammatory bowel syndrome, ulcerative colitis and chron‘z disease mentioned in modern medicine. Most of the symptoms of Irritable Bowel Syndrome are enumerated in the conditions of Vataj Grahani delineated in Ayurvedic Classics. Himashwadi Churna is mentioned in Bhaishajya Ratnawali for Grahani Chikitsa1 . Aim: To clinically evaluate the efficacy of Himanshwadi churna with or without Takradhara on Vataj Grahani(I.B.S.) Materials and Methods: In this present clinical study, total 60 patients of Grahani Roga were registered and randomly divided into two groups. In A group Himanshwasdi churna was given and Group B was given Himanshwadi churna with Takradhara therapy for 4 weeks. A clinical research performa was specially designed on the basis of the study drugs. Results: Excellent results in group A [70-80%] and in group B (70-95%) were found in symptoms like abdominal pain and abdominal discomfort. Both group showed good results [average 50-7o%] were found in symptoms like Adhmanam, Shwas, Aasyavairasya, Grudhi Sarva Rasanam, alteration of bowel habit, Shushka, Tanu, Apakvam, Fenvat Malpravrutti and average results (25- 50%) was found in Manasadanam, Karnaswana, Kruchapaka. Average percent relief in Group A and in Group B was found to be 61.47% and 74.13%, respectively. Therefore, it is more efficacious than group A as per average percent relief. Conclusion: Statistically significant improvement was observed in all the symptoms in both the groups. While in comparison Group A showed better effect than Group B. It is concluded that Himanshwadi churna with Takradhara can be used as rather than without Takradhara Vataj Grahani (I.B.S.)