Synthetic trends followed for the development of 1,3,4-oxadiazole based compounds
Authors: Garima Verma, Mohemmed Faraz Khan, Wasim Akhtar, Mohammad Mumtaz Alam, Mohammad Shaquiquzzaman.
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1,3,4-oxadiazoles, heterocycles bearing one oxygen and two nitrogen atoms in a five membered ring have their application in the diverse areas of medicine. Enough literature is available demonstrating antibacterial, antifungal, anticonvulsant, antiviral, antidiabetic and antimalarial potential of the moiety. Owing to their wide applications, scientists across the globe are engaged in the design and development of oxadiazole derived medicinal agents. This motif can also be traced in a number of drug molecules. Most commonly adopted method for their synthesis includes he reaction between acid hydrazides and acid chorides/carboxylic acids or direct cyclization of diacylhydrazines in the presence of different dehydrating agents like phosphorus oxychloride, thionyl chloride, phosphorus pentaoxide and polyphosphoric acid. This manuscript covers different conventional and non-conventional approaches adopted for the synthesis of 1,3,4-oxadiazole derivatives.