International Journal of Pharmaceutical Chemistry and Analysis

66-72

Authors: Sonal S. Khatavkar, Trupti P. Deshpande, Sameer Zayed, Manoj Zingraji Misal, Pranita Kate

In paediatric patients midazolam and ketamine are commonly used as premedicants. This prospective randomized study was conducted to compare the efficacy of oral midazolam versus combination of midazolam and ketamine as premedicants in paediatric age group in 60 childrens. 30 in each group, aged 2-6 years, undergoing major and intermediate surgery were included in the study. Forty five (45) minutes prior to surgery group A received oral midazolam (0.5mg/kg) and group B received oral midazolam 0.25mg/kg and oral ketamine (3mg/kg) in recovery room. The observations included onset of sedation, reaction to emotions, sedation score, response to intravenous cannulation and face mask acceptance. The data was analysed using chi-square test and unpaired t-test. The results observed in midazolam and ketamine group were statistically significant than in midazolam group alone. Intraoperatively, haemodynamic parameters were comparable in both the groups. There was significant post-operative analgesia in midazolam and ketamine (M+K) group. Thus we conclude oral premedication allays anxiety significantly and results in a calm and co-operative patient. Midazolam as well as midazolam and ketamine (M+K) offers sedation of superior quality. No significant side effects were observed in both the groups. Aims: Midazolam and Ketamine are used in children commonly for premedication. Aim of our study was to find premedicant effects of oral midazolam and midazolam with ketamine in children and any advantages of combination of oral midazolam with ketamine. Methods and Material: Sixty children of age group 2–6 years of A.S.A grade 1and 2 were selected. Group A-midazolam [0.5mg/kg] Group B- midazolam [0.25 mg/kg + ketamine 3mg/kg] Both groups received drug orally 45min before surgery in recovery room with monitored anesthesia care. Onset of sedation, reaction to emotions, score of sedation, mask acceptance and intravenous cannula acceptance were studied. Statistical analysis used: Chi square test and Unpaired t-test. Results: Sedation score, anxiolysis, attitude, reaction to Intravenous cannulation, face mask acceptance, reaction to emotions were studied in both groups. Midazolam and ketamine group results were significant than midazolam group. Intra operatively in both groups pulse rate, oxygen saturation, respiratory rate had no significant difference also post operatively no significant difference was observed in above parameters, post-operative analgesia was significantly better in midazolam with ketamine group. Conclusions: Oral premedication provides good pre-operative condition in terms of co-operation and anxiety. Midazolam as well as combination of Midazolam with ketamine offers sedation of superior quality. No significant side-effects were observed in both groups.

80-83

Authors: Santosh V. Gandhi, Rasika R. Korhale, Swati U. Kolhe

The present work was done to evaluate pharmacokinetic parameters of ritonavir standard, ritonavir crystallo co agglomerates and marketed formulation of ritonavir. The aim of formulation of Ritonavir crystallo co agglomerates was immediate drug release and solubility enhancement. The analysis was carried out by HPLC. The parameters evaluated were Cmax, Tmax, area under curve (AUC 0-t, AUC 0-∞), t1/2, k elimination (ke).

90-98

Authors: Gandla Kumaraswamy, Repeudi Lalitha, K. Vijayaprakash

The present work was aimed at method development and validation for simultaneous estimation of Rosuvastatin Calcium and Aspirin by UV-Spectrophotometric method in pharmaceutical dosage form. In UV method 0.1N NaoH as solvent and λmax of Rosuvastatin Calcium and Aspirin were found to be 232 nm and 222 nm respectively. Concentration ranges were found to be 4-20µg/mL for both drugs. The R2 values were found to be 0.996 and 0.999 for Rosuvastatin Calcium and Aspirin respectively. The method was validated statistically and by recovery studies. Percentage Assay and Recovery were found to be 95-105% for Rosuvastatin Calcium and Aspirin. LOD and LOQ ranges were found to be 0.177 and 0.539µg/mL and 0.298 and 0.903µg/mL for Rosuvastatin Calcium and Aspirin respectively. This method was validated using ICH guidelines.