International Journal of Pharmaceutical Chemistry and Analysis

1-5

Authors: X. Fatima Grace, S. Rahul Raj, S. Shanmughanathan, D. Chamundeeshwari.

Mankind use various products to enhance beauty and elegance to look young and charming. Cosmetics thus play a vital role in human life. Now a days, herbal cosmetic are widely used because of the belief that they have fewer side effects and better safety. Hair is one of the primary parts of the body which acts as a protective appendage. The objective of the present work is to develop a hair oil for general purpose (daily use) using various herbs. The formulated oil was evaluated for its organoleptic properties, acid value, saponification value, refractive index, pH etc. All the parameters were found to be good and within the standards.

14-38

Authors: K.S.G. Arulkumaran, J. Padmapreetha.

Pharmaceutics is a science of preparing and dispensing drugs. It describes the process involved in turning a new chemical entity into medicine. Pharmaceutical analysis describes the sequence such as identification, quantification and determination of the structure of a particular chemical component that is transformed into a drug. International Journal of Pharmaceutical Chemistry and Analysis (IJPCA) is an international, open access, peer review Journal publishing original research & review articles in all the related fields of Analytical and Pharmaceutical Chemistry.

47-57

Authors: Srinivasa Rao Atla, Neelakanta Rao Nagireddy, Rajendra Prasad Yejella.

A new series of 4-arylsubstituted-6-(p-hydroxyphenyl/p-aminophenyl)-3-cyano-2-amino pyridines were synthesized by an efficient one-pot cyclocondensation reaction of 4-amino/4-hydroxyacetophenone, aromatic aldehydes, malononitrile and ammonium acetate. The structures of these compounds were confirmed by IR, NMR (1H & 13C) and Mass spectral analysis. All the synthesized compounds were subjected to evaluation for their anti-inflammatory, analgesic and antimicrobial properties. The electro negativity of the substituents and their displacement on the 4- or 6-aryl ring of the 4,6-diaryl-3-cyano-2-aminopyridine nucleus (4a-p) influenced the anti-inflammatory and analgesic activity which was higher in the presence of electron releasing groups. The introduction of the p-hydroxyphenyl substituent in the 6-position of the 3-cyano-2-aminopyridine nucleus (4i-p) increased the anti-inflammatory and analgesic power, but there was no evidence of the relationship among the electronic characteristic of the substituents, their displacement on the 4-phenyl ring and the activity. These results indicated that 4k and 4p are more promising molecules as anti-inflammatory and analgesic agents. All compounds were also evaluated for their antimicrobial activity against variety of bacterial and fungal strains. Compounds 4b, 4f, 4h, 4j and 4p showed maximum activity comparable to the reference standards.

65-74

Authors: Mr. Prakash Sapra, Dr. Biraju D Patel, Dr. Dhaval V Patel, Dr. Chetan H Borkhataria.

Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by infection of a periodontal pocket arising from the accumulation of subgingival plaque. Periodontal disease has been considered as a possible risk factor for other systemic diseases such as cardiovascular diseases and pre-term low birth weight infants. Aggressive forms of periodontitis can be localized or generalized. Local delivery of antimicrobial agents using controlled release systems should be considered as adjunctive to mechanical debridement for the treatment of localized forms of periodontal destruction. Systemic administration of drugs leads to therapeutic concentrations at the site of infection, but for short periods of time, forcing repeated dosing for longer periods. Local delivery of antimicrobials has been investigated for the possibility of overcoming the limitations of conventional therapy. The use of sustained release formulations to deliver anti-bacterial to the site of infection (periodontal pocket) has recently gained interest. These products provide a long-term, effective treatment at the site of infection at much smaller doses. This article reviews various types of delivery systems evaluated in practical periodontal therapy and identifies areas where further research may lead to a clinically effective intra-pocket delivery system.