The Pharmaceutical and Chemical Journal

5-13

Authors: Upadhyay Uma, Rathore KS

The aim of the current study is to design a sustained release matrix tablet of metformin HCl to maintain plasma level of drug for prolong period of time. Metformin HCl is antihyperglycemic agent used in the treatment of type II Non insulin dependent diabetes mellitus. Sustained release formulation of metformin HCl prolong drug absorption in the upper GI tract and permits once daily dosing in patient with type II diabetes mellitus. This newer formulation may enhance patient compliance compared to conventional immediate release metformin HCl. Metformin HCl present significant challenges due to its poor inherent compressibility, high dose and high water solubility. So matrix tablet of metformin HCl is formulated by different combination of matrix forming polymers such as hydroxypropyl methylcellulose and hydroxylpropyl cellulose by direct compression method. PVPK30 is used as a binder. Magnesium stearate and micro crystalline cellulose are used as a lubricant and filler respectively. Drug and polymer compatibility study is done by IR spectroscopy. The formulated powder mixture is evaluated for precompression parameters such as bulk density, tapped density, angle of repose, compressibility index and Hausner’s ratio for determining flow properties of mixture. Prepared tablets are subjected to post compression parameter such as hardness, thickness, weight variation, friability and drug content. All formulations showed compliance with pharmacopoeial standards. No physicochemical interaction is found between drug and polymers in IR spectrums. It would be desirable in dissolution study that formulation containing lower concentration of polymer will earlier drug release.

20-25

Authors: Raman Kr. Verma, Rishabh Kapoor, Shailendra Kr. Gupta, Rahul R.Chaudhari

Potassium Permanganate (KMnO4) is an oxidizing agent widely used throughout the water industry. It has an effect on the development of a disinfection strategy by serving as an alternative to pre-chlorination or other oxidants at locations in a treatment plant where chemical oxidation is desired for control of color, taste, odor and algae. Potassium Permanganate when exposed in extreme quantity can react with human tissue and causes similar effect as that of acid, it can also cause severe eye irritation on contact and possible burns, may cause chemical conjunctivitis and corneal damage. The objective of this study is to evaluate the ability of activated charcoal to retain Potassium Permanganate ions (K+ and MnO4-) through adsorption in an aqueous solution. On the laboratory scale length of unused bed and equilibrium concentration was found out keeping in mind various parameters like effect of temperature, effect of concentration of adsorbate and flow rate of adsorbate for the removal of KMnO4 ions from water. The isotherm data was verified with the Langmuir adsorption isotherm as well as Freundlich adsorption isotherm equations.

32-33

Authors: Chandan Kumar, Priyanka Gaur, Dr. Sandeep Bhattacharya

The wealth of latest data and knowledge relating to epigenetics obtained in recent years highlights a vibrant future for epigenetics research. It involves the integration of high-throughput sequencing technologies and the means to maintain and manipulate the large amount of data produced by sequencing epigenomes. As more epigenetic markers are associated with specific diseases and tools can be developed to diagnose patients and gauge the severity of disease. There is also great concern in therapeutic epigenetics many drugs, such as DNA methyltransferase inhibitors and histone deacetylase inhibitors are already used in cancer treatment. It is a very exciting time to study epigenetic, and this field of research has the potential to completely transform medicine and greatly improve human lives.