The Histological Effects of Aqueous Extract of Ginger on Adrenal Gland of Adult Wistar Rats
Authors: *1Ezejindu DN, 1Udemezue OO, 1Chukwujekwu IE, 1Anyabolu AE, 2Uchefuna RC, 2Maduka SO, 3Ezejindu CN, 4Ndukwe GU
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This study is aimed at evaluating the histological effects of aqueous extract of ginger on the adrenal gland of adult wistar rats. Twenty adult wistar rats weighing 190-215g were used for the study. They were allocated into four groups (A, B, C and D) of five animals each. Group A animals were served as the control and were orally administered 0.2ml of distilled water; the experimental groups B, C and D were given 0.3ml, 0.6ml and 0.9ml of aqueous extract of ginger respectively for twenty one days. Both the control and experimental groups were weighed, sacrificed under the influence of chloroform vapour and dissected after the last administration. Adrenal gland were harvested, weighed and fixed in 10% formalin for histological studies. The mean final body weight of groups C and D decreased significantly (P<0.05) compare with the control while group B final body weight increased significantly (P<0.05) in comparison with the control group A. The mean relative organ weight of groups C and D increased significantly (P<0.05) when compared with the control while group B was statistically similar with the control group A. Histopathological result revealed abnormality in zona glomerulosa and rearranged cells of steroids in groups C and D. This study therefore suggests that high consumption of ginger may distort the adrenal gland.
Keywords: Ginger, Adrenal gland, Organ weight, Body weight, Wistar rats.