European Journal of Medicine

92-98

Authors: Ignat Ignatov, Christos Drossinakis, Reneta Toshkova, Elisaveta Zvetkova, Iliana Yaneva, Georgi Gluhchev

Studies were conducted with model systems of bio influence (Drossinakis’ method) with electromagnetic (e.m.) fields and infrared thermal field (ITF) (Ignatov et al., 2013). The purpose of research is to analyze effects over DNA. Analysis of effects over water and physiological saline is carried out in the report. Results are achieved with blood serum of hamsters and physiological processes in hamsters with tumors. The water analyses have been conducted with Nonequilibrium Energy Spectrum (NES) and Differential Nonequilibrium Energy Spectrum (DNES) methods (Antonov, 1992; Ignatov, 1998). Experiments were carried out about the influence on tumor cells of mice in water. Reduction of DNES spectrum according to the control sample of cells in healthy animals was observed. (Antonov, 1992). Reduction is also observed in DNES spectrum in blood serum of people having oncological diseases, compared to the one of healthy people (Ignatov, 2012). Such a reduction is most prevalent in (-0.1387 eV; 8.95 µm; 1117 cm-1). In research of the effects of e.m. fields in water and blood serum from hamsters the range is (-0.08 – -0.14 eV) (8.9 –15.5µm) (645–1129 cm-1). Research is conducted for the effects over Graffi tumor that was implanted in hamsters (Toshkova et al., 2019). Studies are conducted with pH and oxidation redox potential (ORP) effects of e.m. fields over physiological saline (Gluhchev et al., 2019).

106-113

Authors: Naina Mohamed Pakkir Maideen

Dihydropyridine Calcium Channel Blockers (CCBs) are widely used as first-line agents to treat hypertension in black patients and in patients aged more than 55 years. They have been identified as the substrates of intestinal and hepatic CYP3A4 enzymes and this review focuses on possible drug-drug interactions of dihydropyridine CCBs involving CYP3A4 enzymes. As object drugs, the dihydropyridine CCBs involved in drug-drug interactions with drugs such as Macrolide antibiotics, Azole antifungals, Protease inhibitors and fruit juices like Grapefruit juice and Seville orange juice and increase the plasma concentrations of dihydropyridine CCBs resulting in enhanced adverse effects. In addition, the drugs like Rifampicin, Phenytoin, and other antiepileptics including Carbamazepine and Phenobarbital decrease the bioavailability of dihydropyridine CCBs. Moreover, as precipitant drugs dihydropyridine CCBs increase the plasma concentrations of Statins and Cyclosporine and decrease the therapeutic efficacy of Clopidogrel. The prescribers and pharmacists are required to be aware of the adverse drug interactions of dihydropyridine CCBs to prevent adverse outcomes.

120-130

Authors: Nedyalka Valcheva

Defined are the physicochemical properties of healing thermal spring waters in the area of Burgas District. It is shown that according to 18 controlled parameters included in the research, the thermal healing spring water village of Shivarovo, thermal healing spring water village of Polyanovo, fulfill the required conditions for drinking water. The spring waters from the given four water sources are characterized by microbiological indicators, as the pathogenic micro-organisms are defined by the membrane method. It is established that thermal healing spring water Burgas Mineral baths, thermal healing spring water village of Shivarovo, thermal healing spring water of village of Polyanovo, fulfill the standard requirements. The healing water of village Judge, District ofBurgas does not conform to the physicochemical indicators given for fluorides, and microbiological indicators with regards to coliform bacteria, Escherichia coli and enterococci. Defined are the physicochemical properties of healing thermal and non-thermal spring waters in the area of Varna District. It is shown that according to 18 controlled parameters included in the research, the thermal healing spring water drilling №Р-83хКК “Saints Constantine and Helena”, thermal healing spring water Р-1х “Aquarium”, thermal healing spring water Р-106 х “Dom Mladost”, thermal healing spring water Р-161х Varna at “Primorski” swimming pool, fulfill the required conditions for drinking water. The spring waters from the given four water sources are characterized by microbiological indicators, as the pathogenic micro-organisms are defined by the membrane method. It is established that thermal healing spring water drilling №Р-83хКК “Saints Constantine and Helena”, thermal healing spring water Р-1х “Aquarium”, thermal healing spring water Р-106 х “Dom Mladost”, thermal healing spring water Р-161х Varna at “Primorski” swimming pool, fulfill the standard requirements. “The healing water” of village Goren Chiflik, District of Varna does not conform with the physicochemical indicators given for nitrates, and microbiological indicators with regards to coliform bacteria and enterococci.