European Journal of Medicine

200-204

Authors: Oksana Y. Feshchuk

The article features the research on bronchial hyperresistivity towards direct and indirect bronchspasmal stimulus among school children with neosinophilious bronchial asthma and deletion polymorphism of genes GSTT1 and GSTM1. Significant risk of further development of children bronchial hyperresistivity is identified. Genotypes: T1+M1del; T1delM1+; T1delM1del. (ОР-6,1 95 %ДИ:2,7-13,7,ОШ-4,2, 95 % ДИ:3,3-5,3, АР-0,29)

215-225

Authors: Sribas Goswami, Manjari Sahai

Infants born preterm are at greater risk than infants born at term for mortality and a variety of health and developmental problems. Complications include acute respiratory, gastrointestinal, immunologic, central nervous system, hearing, and vision problems, as well as longer-term motor, cognitive, visual, hearing, behavioral, social-emotional, health, and growth problems. The birth of a preterm infant can also bring considerable emotional and economic costs to families and have implications for public-sector services, such as health insurance, educational, and other social support systems. The greatest risk of mortality and morbidity is for those infants born at the earliest gestational ages. However, those infants born nearer to term represent the greatest number of infants born preterm and also experience more complications than infants born at term. Preterm birth is a complex cluster of problems with a set of overlapping factors of influence. Its causes may include individual-level behavioral and psychosocial factors, neighborhood characteristics, environmental exposures, medical conditions, infertility treatments, biological factors and genetics. Many of these factors occur in combination, particularly in those who are socioeconomically disadvantaged or who are members of racial and ethnic minority groups. The empirical investigation was carried out to draw correlation between preterm birth and eventuality. This paper deals with various issues related to the premature deliveries from socio-biological perspectives.

241-244

Authors: Nana K. Natsvlishvili, Maradi A. Burduli

The results of microbiological investigation of catarrhal gingivitis on the background of treatment with Unimag are presented in the research. Studies have revealed that treatment with Unimag of the patients with catarrhal and gingivitis rapidly normalizes quantity of microbes in the oral cavity, substituting the gram-negative pathogenic flora for the gram-positive microorganisms in the oral cavity.

254-259

Authors: Nazgul Y. Sarsekeyeva, Bahyt N. Kosherova

The article features literature data for treatment of patients with HIV infections as well as factors for prescription the antiretroviral drugs. The analysis of the VAART use between 1012-13 in Karaganda region was conducted. The data of in-and outpatients with HIV infections are presented. The reasons for treatment cessation and the data of ARV of HIV patients’ tuberculosis are shown.

112-117

Authors: Sharbanu Battakova, Uken Amanbekov, Gulraikhan Miyanova, Mangaz-Dana Fazylova

The article features the research results of psychological status and the nervous system. The study was conducted on the basis of multivariate analysis of morbidity rates of the nervous system with the aim of developing of administrative actions towards the population of Ust-Kamenogorsk. The correlation analysis has shown that the of coefficients of correlation coincide with the analysis data of morbidity rates of the nervous system showing that that morbidity rates are mostly influenced by high concentration of harmful pollutants. Besides, the correlation analysis has allowed identifying the levels of pollution in the atmosphere of the city above which the interrelation between fluctuations of morbidity rates is shown and below which correlation has been not observed. From the provided data we can see that the main sources of harmful substances entering our bodies are polluted atmospheric air and soils. The study revealed that with the growth of anthropogenesis loading by toxic metals, the morbidity rates of encephalopathies of unspecified genesis and the cerebrovascular diseases increase. Changes in psycho-emotional sphere have been revealed. The novelty of research is the development of administrative procedures aimed at reduction of the disease prevalence for people living in Ust-Kamenogorsk.

124-131

Authors: Abdelkrim Berroukche, Malika Bendahmane-Salmi, Abdelkrim Badreddine Kandouci

In West of Algeria, incidence of prostate cancer (PCa) is growing and epidemiological data on benign prostatic hyperplasia (BPH) are contradictory. The prostate specific antigen (PSA) joins other tests, as digital rectal examination (DRE) and ultrasound, for better management of patient. This study aimed to assess the association of previously tests with PSA-assay in diagnosis of PCa and BPH, in West Algeria. A retrospective study was performed on two groups of 234 BPH and 56 PCa diagnosed between 2010–2012 at the urology department of the hospital in Saida. Patients underwent various diagnostic tests; DRE, ultrasound, PSA and pathological examination. BPH is more common than PCa and the most dominant age group was from 70 to 79 years. DRE was positive in 67 % of BPH and 63.3 % PCa. Ultrasound examination revealed that the prostatic structure was heterogeneous in 25.5 % of BPH and 92 % PCa. Total PSA (TPSA) was higher than the cut-off value of 4 ng / ml in 37% of BPH and 75 % PCa. Histological forms of Prostatic adenomyofibroma and prostatic adenocarcinoma were the most represented. This study shows that the combination of different tests is more efficient than using a test alone for a definitive diagnosis of PCa or BPH.

138-143

Authors: Oleksii P. Kmyta

In the article «Genetic factors of fibrinolysis violation and the role of inhibitor plasminogen activator genes polymorphism in the development of secondary thrombus bleeding complications in patients with brain injury», briefly summarized the impact of molecular-genetic mechanisms peculiarities on the system of hemostasis, the results of investigations were provide in case of thrombohemorrhagic complications appearance while PAI-1 plasma levels and computed tomographic manifestations changes in 200 patients with TBI, -675 gene polymorphism and PAI-1.

149-154

Authors: Olena C. Koloskova, Tetiana M. Bilous, Lyudmyla V. Mikaluk

It has been performed complex examination of 150 school-aged children with bronchial asthma, which included a study of exhaled breath condensate and a determination of deletions in the genes of glutathione-S-transferase (GSTM1 and GSTT1). A greater activity of bronchial inflammation manifested by increased activity of oxidative stress with the accumulation of products of oxidative modification of proteins in exhaled breath condensate has been noticed during asthma exacerbation in children with deletion polymorphism of genes GSTT1 and GSTM1 compared with patients without those genetic changes.

166-182

Authors: Vladimir N. Titov

The phylogenetic theory of general pathology postulates that notions of the biological role of arterial pressure (AP) in physiology and pathology have been subjected to inversion. The nephron’s activation of the synthesis of the components renin → angiotensin-II (A-II) and the augmentation of aldosterone secretion are directed not at an increase in AP but at preserving the volume of the piece of the third world ocean, privatized by each species, - the pool of the intercellular milieu in which, just like millions of years before, there continue to live all cells. Phylogenetically earlier organs cannot regulate the action of a later one in AP phylogenesis – a physical factor in metabolism regulation. It is not the kidneys that increase AP but the vasomotor center, which, increasing AP in the proximal segment and further hydrodynamic pressure in the distal segment of the arterial bed, seeks to reanimate the function of nephrons, the biological function of endoecology and the biological reaction of excretion. In addition to playing a major role in the biological function of locomotion, AP is a physical factor in compensating for impairments in the biological functions of homeostasis, trophology, endoecology, and adaptation. There have formed sequentially three levels of metabolic regulation in phylogenesis. At an autocrine level, there occurs a specific regulation of biochemical reactions. Within paracrinally regulated communities of cells, in the distal segment of the arterial bed, metabolism is regulated by millions of local peristaltic pumps through compensating for the biological reaction of endothelium-dependent vasodilation, microcirculation, and the action of humoral mediators and hormonal principles. In vivo from the level of the vasomotor center metabolism is non-specifically, systemically regulated by the physical factor – AP – through sympathetic activation of the heart; in the proximal segment of the arterial bed and the distal one, AP, overcoming the resistance, virtually “collapses” arterioles with impaired microcirculation. A-II acts as a vasoconstrictor only in the distal segment of the arterial bed. In the pathogenesis of essential, metabolic AH, the paracrine communities of the nephron and the kidney are involved in the realization of pathological compensation secondarily and are often “wrongfully accused”, just like the other “target organs” – the brain, the lungs, and the heart.

52-56

Authors: Aleksandr N. Bitsadze

The article studies the possibilities of the application of the principle of biological rheoencephalogram feedback in rehabilitation of patients with cerebrovascular diseases in resort environment, detects positive dynamics of rheoencephalogram measures and the symptom index in the patients with vascular dyscirculatory encephalopathy with the use of functional biocontrol, which proves the clinical efficiency of the method of treatment and rehabilitation procedures, applied in the patients with cerebrovascular diseases.

65-71

Authors: Ekaterina A. Filippova, Alexander V. Korobeynikov, Denis V. Lozhkarev

The article considers the clustering of the parameters of man’s heart rate variability. The technique of parameters calculation and diagrams of rhythmographic analysis construction are presented. The algorithm of conceptual clustering Cobweb, modified for quantitative data, is used for parameters clustering. The results of the experiments prove the efficiency of the division of the learning range of electrocardiograms into the groups similar in terms of rhythmographic parameters. The practical application of the offered method as a part of the software support of electrocardiograms analysis will enable to provide operational evaluation of the rhythmographic nature of heart function in the course of screening examinations or in the emergency medicine for diagnosing and prediction.

87-100

Authors: Alexandr N. Oleshko

Injuries are among the most frequent causes of hospitalization in emergency surgery clinics. Currently, the incidence of injuries in the population is 1:1000 per year, and the mortality rate ranges from 1.5 to 5.9 %. For treatment of wounds uses a wide range of the local application on the basis of natural and artificial ingredients. In recent decades, a number of studies devoted to the use of chitosan for the treatment of wounds of various etiologies. But data regarding the activities of chitosan-based materials on the treatment of wounds of mechanical etiology in age aspect are pure. The aim of our research – the study of the parameters of wound surface in animals of different ages during the application of chitosan membranes. The experiment was conducted on 180 laboratory animals – young, mature and old age, which simulated mechanical trauma in interscapullar area. Experimental series were carried out daily applique innovative chitosan membranes. To control the process of skin regeneration was used method of planimetric study. Age features of mechanical etiology wound healing are to reduce the speed of cleaning the surface of the necrotic mass and slowing the formation of the epithelial layer. Application of chitosan membranes for the treatment of mechanical trauma leads to an acceleration of cleansing the wound from necrotic tissue, increased the speed of transformation of granulation in the connective tissue and as a result – complete epithelialization of the defect without scar formation.

4-7

Authors: Mohamed S. Al-Braich, Nada K. Al-Husaini, Sama H. M. Saleh, Munira F. Awn

Adiponectin is protein secreted from adipose tissue and plays important role in regulating glucose level as well as fatty acid breakdown. Adipose tissue has been considered an important endocrine organ. Adiponectin has been shown to completely reverse insulin resistance. A total of sixty subjects involved in this study to examine the regulatory roles of adiponectin concentration in diabetic type II postmenopausal women and to study the correlation between the parameters (serum glucose, cholesterol and triglyceride). Thirty of each diabetic women (BMI<30) and healthy postmenopausal women (BMI<30) were selected from Baghdad teaching hospital in Baghdad/ Iraq. ELISA (enzyme linked immune sorbent assay) technique was used for the measurement of serum adiponectin. Blood glucose, cholesterol and triglyceride were determined by using colorimetric method. Results showed that the level of serum adiponectin in diabetic postmenopausal women were significantly (P < 0.01) lower than that of non diabetic postmenopausal women. Serum glucose in diabetic postmenopausal women was significantly (P < 0.01) higher than non-diabetic women. The present study indicates the possibility of future development of new anti-diabetic agents that act independent of insulin action.

17-28

Authors: Natalia H. Horovenko, Svitlana V. Podolska, Zoryana R. Kocherha

It has been established that the frequency of polymorphic variants of GSTM1 "+" genes was 43.70 % and the frequency of polymorphic variants of GSTM1 "-"genes made up 56.30 % correspondingly in all newborns in the region, without division into ecological zones. Speaking about GSTT1genes the frequencies of polymorphic variants of GSTТ1«+» and GSTТ1«-» were 80.67 % and 19.33 % correspondingly. Positive micro-nucleus test was found in none of the carriers of GSTТ1«-» polymorphic variant. GSTT1«+» allelic variant was found in all newborns with negative micro-nucleus test. 78.38 % predominance in associations of GSTM1«+»/GSTT1 genotypes is characteristic of newborns with negative micro-nucleus test. Our studies have shown the diagnostic value of molecular-genetic testing in conjunction with the micro-nucleus testing for predicting newborns’ genome sensitivity to total exposure of environmental factors.

43-48

Authors: Mikhail Yu. Vereshchagin, Aleksandr U. Minkin

There is a growing number of patients with malignant tumors of nasal cavity and paranasal sinuses. Majority of patients with this pathology are hospitalized with III-IV cancer stages. There is no tendency to decrease the advanced stage of cancer. The efficiency of patients’ treatment can be increased by early diagnostics. The main reason of delayed diagnostics is insufficient oncologic alarm in primary health care. While the background prodromic cancer processes are morphologically detected in 56.7 % of patients, the issues of treatment policy during cavity and paranasal sinuses premalignancy are still unsettled. Chronic polypous rhinosinusitis is one of the most frequent background process of cancer of nasal cavity and paranasal sinuses. Rhinosinusitis morbidity is high; the growth of its incidence is 2–4 % per year in the last decade. There are few works, considering polypous rhinosinusitis as premalignant condition.