European Journal of Medicine

112-117

Authors: Sharbanu Battakova, Uken Amanbekov, Gulraikhan Miyanova, Mangaz-Dana Fazylova

The article features the research results of psychological status and the nervous system. The study was conducted on the basis of multivariate analysis of morbidity rates of the nervous system with the aim of developing of administrative actions towards the population of Ust-Kamenogorsk. The correlation analysis has shown that the of coefficients of correlation coincide with the analysis data of morbidity rates of the nervous system showing that that morbidity rates are mostly influenced by high concentration of harmful pollutants. Besides, the correlation analysis has allowed identifying the levels of pollution in the atmosphere of the city above which the interrelation between fluctuations of morbidity rates is shown and below which correlation has been not observed. From the provided data we can see that the main sources of harmful substances entering our bodies are polluted atmospheric air and soils. The study revealed that with the growth of anthropogenesis loading by toxic metals, the morbidity rates of encephalopathies of unspecified genesis and the cerebrovascular diseases increase. Changes in psycho-emotional sphere have been revealed. The novelty of research is the development of administrative procedures aimed at reduction of the disease prevalence for people living in Ust-Kamenogorsk.

124-131

Authors: Abdelkrim Berroukche, Malika Bendahmane-Salmi, Abdelkrim Badreddine Kandouci

In West of Algeria, incidence of prostate cancer (PCa) is growing and epidemiological data on benign prostatic hyperplasia (BPH) are contradictory. The prostate specific antigen (PSA) joins other tests, as digital rectal examination (DRE) and ultrasound, for better management of patient. This study aimed to assess the association of previously tests with PSA-assay in diagnosis of PCa and BPH, in West Algeria. A retrospective study was performed on two groups of 234 BPH and 56 PCa diagnosed between 2010–2012 at the urology department of the hospital in Saida. Patients underwent various diagnostic tests; DRE, ultrasound, PSA and pathological examination. BPH is more common than PCa and the most dominant age group was from 70 to 79 years. DRE was positive in 67 % of BPH and 63.3 % PCa. Ultrasound examination revealed that the prostatic structure was heterogeneous in 25.5 % of BPH and 92 % PCa. Total PSA (TPSA) was higher than the cut-off value of 4 ng / ml in 37% of BPH and 75 % PCa. Histological forms of Prostatic adenomyofibroma and prostatic adenocarcinoma were the most represented. This study shows that the combination of different tests is more efficient than using a test alone for a definitive diagnosis of PCa or BPH.

138-143

Authors: Oleksii P. Kmyta

In the article «Genetic factors of fibrinolysis violation and the role of inhibitor plasminogen activator genes polymorphism in the development of secondary thrombus bleeding complications in patients with brain injury», briefly summarized the impact of molecular-genetic mechanisms peculiarities on the system of hemostasis, the results of investigations were provide in case of thrombohemorrhagic complications appearance while PAI-1 plasma levels and computed tomographic manifestations changes in 200 patients with TBI, -675 gene polymorphism and PAI-1.

149-154

Authors: Olena C. Koloskova, Tetiana M. Bilous, Lyudmyla V. Mikaluk

It has been performed complex examination of 150 school-aged children with bronchial asthma, which included a study of exhaled breath condensate and a determination of deletions in the genes of glutathione-S-transferase (GSTM1 and GSTT1). A greater activity of bronchial inflammation manifested by increased activity of oxidative stress with the accumulation of products of oxidative modification of proteins in exhaled breath condensate has been noticed during asthma exacerbation in children with deletion polymorphism of genes GSTT1 and GSTM1 compared with patients without those genetic changes.

166-182

Authors: Vladimir N. Titov

The phylogenetic theory of general pathology postulates that notions of the biological role of arterial pressure (AP) in physiology and pathology have been subjected to inversion. The nephron’s activation of the synthesis of the components renin → angiotensin-II (A-II) and the augmentation of aldosterone secretion are directed not at an increase in AP but at preserving the volume of the piece of the third world ocean, privatized by each species, - the pool of the intercellular milieu in which, just like millions of years before, there continue to live all cells. Phylogenetically earlier organs cannot regulate the action of a later one in AP phylogenesis – a physical factor in metabolism regulation. It is not the kidneys that increase AP but the vasomotor center, which, increasing AP in the proximal segment and further hydrodynamic pressure in the distal segment of the arterial bed, seeks to reanimate the function of nephrons, the biological function of endoecology and the biological reaction of excretion. In addition to playing a major role in the biological function of locomotion, AP is a physical factor in compensating for impairments in the biological functions of homeostasis, trophology, endoecology, and adaptation. There have formed sequentially three levels of metabolic regulation in phylogenesis. At an autocrine level, there occurs a specific regulation of biochemical reactions. Within paracrinally regulated communities of cells, in the distal segment of the arterial bed, metabolism is regulated by millions of local peristaltic pumps through compensating for the biological reaction of endothelium-dependent vasodilation, microcirculation, and the action of humoral mediators and hormonal principles. In vivo from the level of the vasomotor center metabolism is non-specifically, systemically regulated by the physical factor – AP – through sympathetic activation of the heart; in the proximal segment of the arterial bed and the distal one, AP, overcoming the resistance, virtually “collapses” arterioles with impaired microcirculation. A-II acts as a vasoconstrictor only in the distal segment of the arterial bed. In the pathogenesis of essential, metabolic AH, the paracrine communities of the nephron and the kidney are involved in the realization of pathological compensation secondarily and are often “wrongfully accused”, just like the other “target organs” – the brain, the lungs, and the heart.