Photoacoustic Blood Oxygenation Imaging Based on Semiconductor Lasers
Authors: Claus-Stefan Friedrich, Martin P. Mienkina, Carsten Brenner, Nils C. Gerhardt, Manfred Jörger, Andreas Strauß, Martin F. Beckmann, Georg Schmitz, Martin R. Hofmann
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We present a multi-wavelength semiconductor laser system in combination with a standard clinical ultrasound system for photoacoustic blood oxygenation imaging. We demonstrate its ability to measure blood oxygenation quantitatively. To model human whole blood properties we used porcine whole blood samples. The resulting oxygenation values are in good agreement with the values obtained by a commercially available blood oxygenation measurement system (R2=0.96) over a wide range of oxygen saturations. By using a blood vessel mimicking sample we demonstrate quantitative spatially resolved oxygenation imaging.