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Metal-Ligand Stability Constants of Lanthanide(III) Chelates with some Substituted Drugs
Authors: SONUNE K.N., MESHRAM Y.K., DEVHADE J. B.
Number of views: 395
The interaction of Ce(III),Pr (III),Nd (III),Sm (III),Gd (III), Dy (III),Yb (III) and
Lu (III) metal ions with 7-chloro-5-(o- chloro phenyl)-1, 3-dihydro-3-hydroxy-2H-1, 4-
benzodi Drug (ligand-1) and 7-chloro-5-phenyl -1, 3-dihydro-3-hydroxy -2H-1, 4-
benzodi Drug (ligand-2) have been investigated by pH-metric technique at 0.1 M ionic
strength at ±0.1 0C in 70% dioxane– water mixture.The data obtained were used to
estimate the value of proton-ligand stability constant(pK) and metal- ligand stability
constant(log K).It is observed that Ce(III), Pr (III), Nd (III),Sm (III),Gd (III),Dy
(III),Yb (III) and Lu (III) metal ions formed 1:1 and 1:2 complexes with all the ligands.