The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

10-21

Authors: A. N. Yabluchanskiy

Hemorrhagic stroke in response to intracerebral hemorrhage is considered an aseptic form of inflammation. With this in mind the dynamics of leukocytes changes in blood and in the hemorrhagic stroke zone as main factors of inflammation are examined. Sprague-Dawley rats (N = 24) underwent surgical procedures and were divided into two groups — control group and a hemorrhagic stroke group — an injection of 2 µL of sterile saline and 2 µL of 0,2U of Collagenase-IV (S) respectively. White blood cells count analysis, combined histological and immunohistological examination with further densitometric and statistical analysis of blood and hemorrhagic stroke zone leukocytes were performed. A synchronized increase in blood and hemorrhagic stroke zone levels of both polymorphonuclear and mononuclear leukocytes was observed, highlighting the inflammatory nature of hemorrhagic stroke. A delay of 48 hours between peak levels of polymorphonuclear and mononuclear leuokocytosis both in blood and the hemorrhagic stroke zone was established. Therefore, understanding hemorrhagic stroke as one of the forms of aseptic inflammation suggests alternate perspectives in the development of new approaches to diagnosis and treatment including interventions into kinetics of blood and hemorrhagic stroke zone leukocytes.

29-33

Authors: N. M. Zheleznyakova

The article deals with aspects of quality of life of patients with isolated COPD and combined with chronic pancreatitis (CP). Quality of life was assessed with general medical (SF-36 questionnaire) and specialized respiratory (St. George’s Hospital Questionnaire — SGRQ) questionnaires quality of life. It was found that the accompanying CP has a negative effect on quality of life of patients with COPD.

39-45

Authors: O. O. Lutsak, L. P. Parashchenyuk, P. M. Babych, L. G. Voronkov

Total score of standardized CHF-specific QOL survey MLHFQ, as well as it changes during treatment allow to foresee in approximation chances for survival in the patients with CHF of III–IV NYHA functional over the following 6 and 12 months of treatment. Total MLHQL score exceeding 72 (HR = 2,64) is an infor-mative predictor of patients’ with manifested CHF non-survival over the following 6 months. Total MLHQL score exceeding 69 (HR=2,34) is an informative predictor of patients’ with manifested CHF non-survival over the following 12 months. Increase in the total score in > 2,5 is a predictor of patients’ with clinically mani¬fested CHF over the following 6 months (HR = 4,97) and 12 months (HR = 3,50).

50-56

Authors: A. V. Muzhichuk

On base of a comprehensive survey of 248 patients with different thyroid pathology, artificial neural network has been created. Its task was to predict the possibility of cancer risk in patients with thyroid benign pathology. Neural network training based on the data of surveys carried out 120 patients, testing according to 128. Trained artificial neural network is highly flexible with regard to the different variants of the background benign pathology and capable with high sensitivity (89,5 %) and specificity (80,3 %) forecast the existence of hidden currents or probability of occurrence in future thyroid cancer in patients with benign pathology.

65-71

Authors: N. P. Kopitsa, Ya. V. Gileva, N. V. Belaya

Vascular inflammation plays a key role in atherogenesis. In this regard, in cardiology for clinical evaluation of patients are widely being used biomarkers reflecting inflammation in the organism, as their increasing is associated with an increased risk of cardiovascular disease development. Determining of the level of one of these biomarkers — lipoprotein-associated phospholipase A2 (Lp-FLA2) along with the already widely used C-reactive protein promises to significantly improve the detection of high-risk patients especially in acute coronary syndrome, as well as to assess the adequacy of therapeutic strategy.

88-101

Authors: M. I. Shevchyk, L. A. Martimyanova, N. I. Iabluchanskyi

This review discusses the importance of the QRS complex duration in patients with hypertension. QRS complex of ECG reflects the functional state of the myocardium — isovolumetric contraction and systole de-fining the entire follow-up of the heart. The change in QRS complex duration of hypertension is an important marker for early detection of ECG myocardial hypertrophy, the risk of arrhythmias, ECG changes the picture when combined with concomitant diseases and conditions, the effectiveness of antihypertensive therapy.

105-111

Authors: V. A. Strikhar, A. N. Fomich, N. I. Yabluchansky

An example of the clinical case demonstrates a significance of the correct diagnosis and treatment of is-olated diastolic arterial hyper-and hypotension in patient with sympathetic distress and atherosclerosis. Research methods comprised lipid profile, heart rate variability, blood pressure monitoring and Holter ECG. The crucial role in the treatment of the patient belonged to biofeedback and medical therapy with atorvasta-tin and cinnarizine.