The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

7-16

Authors: N. I. Yabluchansky, N. V. Makienko, L. A. Martimyanova, N. V. Lysenko, O. Yu. Bychkova

The study examined the development of historical understanding of the origins of one strategy for athero-sclerosis and hypertension in adults. It is shown that the last are based on a single target, in many ways on a unique nature and violation mechanisms on a local and systemic levels, which involve cholesterin meta¬bo-lism, nervous regulation and generated and modified chronic inflammation.

22-27

Authors: K. A. Apykhtin, A. V. Shvets

This article is about correlation between HRV-indices and mental efficiency indices in persons with dif-ferent level of mental efficiency. It was observed, that mental efficiency in persons with high level of it sup-plies with parasympathotonia and is assotiated with total HRV increase and centralisation degree reduction. Mental efficiency in persons with low and medium level of it supplies with centralisation degree increase and reduction of absolute and specific vagal tone.

32-38

Authors: V. L. Kulyk

In 64 patients (41 males and 23 females) aged (65 ± 12) years with atrial fibrillation (AF) studied the ef-fect of a combination of amiodarone and beta-blockers (BB) on the clinical signs of AF depending on the du-ration of the QTc. As a result of therapy in patients with AF in a subgroup of normal QTc observed more significant decrease of functional class of heart failure and stable angina, the degree of hypertension, reduced frequency of ventricular contractions, and systolic and diastolic blood pressure, improving the pumping func-tion heart than in the subgroup of long QTc. Tendency to further increase of the initially prolonged QTc inter-val duration with therapy of amiodarone and BB combination requires strict control in such patients.

44-48

Authors: I. S. Lebets, A. V. Letjago, E. V. Matvienko

A study of disease-concept types (DCT) using A.E.Lychko’s «Pathocharacter Diagnostic Adolescent’s Inventory» and H. Eisenk’s «Neurotism Inventory» in 106 adolescents at the age of 16–18, with osteo-arthrosis (OA), has been carried. The patients have been divided into research groups on the basis of sex (77 girls, 29 boys) and OA duration (less than a year ― 46, more than a year ― 60). It has been established that the principal clinical sign of OA consisted in the pain in affected joints taking place after a physical activity, in the evening, going downstairs, and in prolonged terms of pathology ― on ordinary activities. A disease-concept in adolescents has been estimated. The most frequent DCT reflected more possibilities of adaptation (ergopathic, anosognostic, harmonic). Character accentuation (CA) versions have been detected. The girls manifested mostly hysteroid, labile and epileptoid CA, while schizoid and epileptoid CA has been more frequent in boys. ⅓ of patients manifested emotional instability.

54-58

Authors: I. Yu. Rybalchenko, I. V. Soldatenko, L. O. Martіmyanova

A total of 130 patients with permanent atrial fibrillation (AF) (78 men and 52 women) aged (64 ± 9 years) were observed. The average duration of AF was (6 ± 5) years. Depending on the class of QRS complex dura-tion (QRS) patients were divided into two subgroups — with normal QRS duration (NQRS) and with pro-longed QRS (LQRS). Prognostic significance of clinical signs and hemodynamic parameters in assessment of the effectiveness of permanent AF control was determined retrospectively on the medical therapy results via step discriminant analysis in two subgroups of patients. Among the studied clinical signs and hemodynamic parameters (age of the patients, AF duration, prescription, severity of the symptoms of AF (EHRA), degree of hypertension, functional class of stable angina and heart failure, systolic and diastolic blood pressure, ventri-cular rate (VR), QRS duration, the anteroposterior size of the left atrium, left ventricular (LV) end-diastolic volume, end-systolic volume, posterior wall thickness and ejection fraction) statistically significant criteria for the effectiveness of permanent AF control for the patients with NQRS was VR and for the patients with LQRS — QRS duration and LV posterior wall thickness.

63-67

Authors: E. Yu. Shmidt, A. L. Kulik, A.V. Martynenko, N. I. Yabluchansky

In 25 patients with arterial hypertension (11 women and 14 men, mean age 56,8 ± 5,7 years), biofeedback efficacy in a closed loop of heart rate variability (HRV) and paced breathing (PB) in the control of blood pressure (BP ) and heart rate (HR) was studied. Patients were divided into 2 groups: 1 — biofeedback group (13 patients) and 2 — and the comparison group (12 patients). Patients in the biofeedback group underwent 5 biofeedback sessions, to patients in the comparison group only 2 biofeedback sessions were performed — on admission and before discharge from hospital. The effectiveness of biofeedback was evaluated by comparing systolic and diastolic blood pressure values (SBP and DBP, respectively), HR and the integral biofeedback quality index (BQI) on admission and discharge from hospital in both groups. The results showed that the closed loop biofeedback of HRV and the PB allows to further reduce the SBP, DBP and HR with medical therapy background, and the BQI positive dynamics in the biofeedback group indicates the existence of the regulation system «training» effect as a result of biofeedback.

74-82

Authors: A. Yu. Volyansky, E. A. Romanova, N. N. Popov

Ukraine’s story of the state of vaccinal preventyion of viral infections (poliomieliyis, measles, rubella, mumps, hepatitis B) literature review is offered. Latest publications that contain specific phyprolaxis of viral infections problems in our country are given.

94-99

Authors: О. Yu. Bychkova, V. M. Savchenko, O. Е. Tomina, A. Yu. Kartvelishviliy

Clinical pharmacology of hepatotropic drug in the international system of ATC (anatomic-therapeutic-chemical) drugs classification is described. The classification, pharmacokinetics and pharmacodynamics charac¬teristics, indications and principles of using drugs from this group in a therapeutic clinic are repre¬sented. Are considered Contraindications, side effects and interactions with other hepatotropic drugs are considered.