The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

13-16

Authors: R. Yа. Abdullayev, T. G. Grigoryeva, G. A. Oleynik, S. G. Yefimenko

For the first time ultrasonic research of the condition of short tubular bones of extremities in patients with local cold injuries (frostbites) was carried out. The appreciable damages of a cortical layer of periosteum, internal diameter of bones even in prereactive period of cryoinjury were revealed. The received results have allowed to define the proper tactics and timeliness of carrying out of conservative and surgical treatment.

22-27

Authors: N. G. Gravirovska, О. I. Zalyubovskа

Study of regional prevalence and morbidity indexes of chronic gastroduodenitis in Kharkov and Dnepropetrovsk regions and their dynamics within 10 years allowed to determine their substantial discre-pancy and fluctuation. Increase of growth rate of prevalence (up to 110,8%) and morbidity (up to 220,9%) in Kharkov region, that is 13,6 times higher than average statistical index in Ukraine, has been determined. Study of such tendency reasons on the model of polyclinics showed that these indexes are significantly higher in the industrial area of the city with reduced standard of living of the population than in the area with more satisfactory social conditions of the population. The results are a cause to improve the dispensary methods using the advances of modern medicine.

32-36

Authors: N. P. Kopitsa, O. V. Degtyarevа, O. V. Petynina

One of the achievements of recent years in the field of cardiology is to create a model for risk assessment of patients with acute coronary syndrome (ACS), which allows you to select the most optimal treatment strate¬gy. In clinical practice used models for calculating risk TIMI, GRACE, PURSUIT, based on clinical data, ECG, assessment of biochemical markers. In order to improve forecast accuracy in our study, we used the most popular scale of GRACE in conjunction with indicators of the N-terminal region prohormone brain natriuretic peptide (NT-proBNP) in 126 patients with ACS for short-and long-term prognosis. We found that the highest level of cardiac mortality was observed in patients with indicators GRACE> 4 and at the level of NT-proBNP> 1271 pg / ml.

40-45

Authors: I. V. Lakhno, A. E. Tkachov

It was performed the investigation of the fetal heart rate variability and umbilical vein blood flow in preg¬nant women with preeclampsia. It was found that severity progression of preeclampsia has been associated with the total level autonomic nervous regulation reduction. The role of slow hemodynamic processes in the fetal homeostasis maintaining has been encreased on this background. The fetal growth retardation was accompanied with the deterioration of blood flow in the umbilical vein. The slow oscillations of hemodynamics in the umbilical vein those were not accompanied with the fetal movements and respiratory activity was a protective mechanism for the growth restricted fetus. These oscillations have increased the transport of oxygen and nutrients to the fetus.

52-59

Authors: N. N. Popov, A. N. Savvo, E. G. Koliushko

The purpose of the present research was studying of efficiency of application of an intravenous immunoglobulin in treatment of often ill children by sharp respiratory virus infections with a syndrome lymphadenopathy. The obtained data specifies that application ВВИГ allows about treatment terms, in 3 times reduces disease DRS within a year, warns development of bacterial complications, liquidates lympha-denopathy. At children receiving VVIG, dynamical increase of local and system immunity, activization of anti-virus immunity, normalization of funktsional th activity of lymphocytes and phagocytes cages is ob-served. Under the influence of VVIG spontaneous and IL-2-induction proliferative activity of lymphocytes, and also spontaneous production IL-2 and IL-10 at patients decrease to normal values. The offered therapy allows to normalize in short terms it-munnye processes with which development of lymphadenopathy associates.

64-72

Authors: V. P. Starenkiy, O. M. Sukhina, M. V. Bielozor

The analysis of the results of radiation therapy (RT) using different fractionation regimes among 82 patients with IIIA and IIIB stage non-small-cell lung cancer (NSCLC) was held. All of the patients were divided into three groups: the first one (consisted of 30 patients) – standard RT; the second one (consisted of 27 patients) – accelerated hyperfractionated RT; the third one (consisted of 25 patients) – RT using an accelerated regime with the dose escalation and etoposide chemomodification. There was an overt effect observed in the groups 2 and 3 (74,1±8,6% and 72±9,2% in the groups 2 and 3 respectively against 40±8,9% in the group 1 p<0,05). In this groups high annual survival rate is observed (66,7±9,2% and 64±9,8% respectively against 43,3±9,0% in the group 1 p>0.05). However, early I-II grade radiation pneumonitis were observed rarer in the groups 1 (16,7±6,8%) in comparison with the groups 2 and 3 (37±9,5% and 36±9,8% respectively). Patient’s life quality improvement was observed in all of the groups, however, clinical effect comes in 2-3 weeks earlier in case of an accelerated RT administration. Late radiation changes of pulmonary tissues exercise a significant negative influence on life quality of NSCLC patients after the RT had been held for the period of 3 to 8 months of observation as a result symptomatic therapy is to be administered during the stages of RT and follow-up care.

77-82

Authors: O. E. Tomina, O. Yu. Bichkova

In out-patient conditions patients with hypertension were investigated (n=99): of which the core group consisted of patients with hypertension (H) comorbid with peptic ulcer (PU) and the comparison group con-sisted of patients with isolated H. In all patients, assessed clinical features (age, level and stage of Н, stage and functional class of heart failure), the spectral indices of heart rate variability (HRV), the types of orthos-tatic responses and circadian blood pressure. Determination of prognostic criteria for effective control of blood pressure in population studied parameters was solved by constructing the equations of dividing func-tions. Prognostically significant parameters for effective control of blood pressure in the group of comorbid disease were age, total power HRV and the index of sympathoparasympatetic balance, the group isolated H – diastolic blood pressure, total power HRV and the index of sympathoparasympatetic balance. Most significant parameter influencing the efficacy of blood pressure control rate was sympathoparasympatetic balance HRV, and the least powerful – the diastolic blood pressure.

88-97

Authors: G. M. Fomych

Existing data on the orthostatic responses of heart rate (HR), their frequency, prevalence, etiological fac-tors, pathophysiological mechanisms, research methods and differential diagnosis are analyzed in this review. Certain types of orthostatic HR responses and their relationship to pathological states and use of different drug groups are studied. Methods for determining the orthostatic HR reactions, active and passive orthostatic tests, existing approaches to the correction of pathological types and prognosis are discussed.

108-114

Authors: А. V. Bondarenko

The role of Bartonella henselae in development of one of the variants of bartonellosis – catscratch disease represented in the article. The recent conceptions on epidemiology of disease (possibility of existence of other sources of infection) and peculiarities of pathogenesis taking into account immune status of patient reviewed. Different clinical variants of infection and methods of their diagnostics, treatment and prophylaxis discussed. Different clinical variants of infection, methods of their diagnostics, necessity of etiotropic therapy conducting and questions of prophylaxis discussed.