The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

5-12

Authors: A.V. Muzhychuk, N.I. Afanasyeva, V.V. Muzhychuk, V.I. Starikov, Y.A. Vinnik, V.V. Michalycyn

128 samples of removed thyroid gland tissue were studied. In all cases differentiated thyroid cancer was diagnosed. We analyzed the results of immunohistochemical staining for p53, p21WAF1/CIP1 and p63 and the correlation with presence and type of patients burdened heredity. Established, that the expression of studied markers in tumor of patients, which had a healthy family, was at lowest level. The expression rates were high-er in patients whose relatives had various non-neoplastic thyroid pathology. The highest rates of markers expression observed in patients with cancer burdened heredity. In paratumor tissue the trends of markers expression changes in patients with burdened heredity, although were less pronounced, but had similarities with malignant tumors.It indicates that the molecular-genetic dis-order is occurring not only in tumor but also in nonmalignant cells. This fact obviously is in favor of the hy-pothesis that the effect of such disorders may be the malignant tumor appearance.

17-21

Authors: E.V. Sirenko

The ability of subtoxic dozes of organic mixes to ingibit activity of flavin- and piridin dehydrogenases, the disorders of ORP and synthesis processes was presented. It was registered the morphologic disoders in the tissue of liver, had brain, kidney, adrenal glands: the degenerative atrophy, caused toxic action of organic substances, which negatively influences tissues of organs. Influence of ksenobiotics caused some changes of a functional adaptive pressure of a homeostasis, endocellular metabolism, albuminous and exchanges.

31-37

Authors: І.Yu. Burdа

Relationship between the QRS complex duration (QRSD) and clinical manifestation of atrial fibrillation (AF) was studied in 126 patients mean age (65±10) years with duration of the disease (6±5) years. In study population the range of QRSD was (65-190) ms. Of these patients, 54 % had prolonged QRS complexes, shortened QRS complexes were absent. The frequency of intraventricular blocks in patients with normal QRS complex was 14% and with prolonged – 41%. Patients with prolonged QRS complex and intraventricular blocks had more severe clinical manifestation of AF, than without blocks. Left bundle branch block and bifascicular block were associated with more severe clinical manifestation of AF than other types of intraventricular blocks. QRS complex prolongation was associated with the increase in severity of heart failure and arterial hypertension, left atrial anteroposterior diameter, left ventricular (LV) end-diastolic diameter, LV posterior wall thickness and decrease of the LV ejection fraction and heart rate.

42-46

Authors: N.P. Kopytsa, O.I. Lytvyn

Atherosclerotic plague destabilization is defined as strengthening of chronic inflammation process activity and is the reason of acute coronary syndrome (ACS). ACS manifests C-reactive protein (CRP) level increasing. In contrary, anti-inflammatory processes activate – Interleukin-10 (IL-10) level increases. The aim of study was to determine prognostic value of CRP and IL-10 for the ACS outcomes in 6 month after coronary event. The aim realized with the assistance of the using the new coefficient of the reduction level IL-10. This coefficient allows to predict with high probability recurrent coronary events in patients after ACS.

53-55

Authors: A.L. Kulik, A.K. Zaderihin, V.I. Shulgin, A.V. Martynenko, М.I. Iabluchanskyi

At 4 healthy volunteers in age from 22 to 29 years (2 men and 2 women) with the body mass index from 21 to 23 kg/m2 the comparison of different methods of optimal frequencies of paced breathing detection, at which the greatest approximation to the optimum ratio of spectral indices of heart rate variability (HRV) was achieved were studied. Detection of optimal frequency was performed by enumeration of breathing frequency (BF) – increase and decrease from 6 to 12 breaths per minute and back, and by using automatic algorithm. The results showed the coincidence of optima obtained by stepwise increasing and decreasing of BF with data from automatic search, that indicates the possibility of method algorithmization and sufficiently high accuracy and reliability of the proposed algorithm.

61-65

Authors: I.V. Soldatenko

Studied The effectiveness of controls comorbid with osteoarthritis (OA) hypertension (H) at stages of therapy in the light of day profile of systolic blood pressure in 43 patients aged 59 ± 10 years. The study involved 23 patients with comorbid with OA H (H + OA), 20 with isolated H (IH). Found that age-comorbidity of hypertension increases with greater frequency of occurrence in females. Osteoarthritis increases the severity of hypertension without significant effect on baseline blood pressure in the daily profile of systolic blood pressure. Control of blood pressure is equally effective in patients with comorbid with osteoarthritis and isolated arterial hypertension. Effectiveness of controls was higher in patients with non-dippers and below – with dippers and night-peakers circadian blood pressure profile. Comorbid with osteoarthritis as well as isolated, arterial hypertension and dippers and night-peakers day profile of systolic blood pressure requires a more intensive antihypertensive therapy.

71-75

Authors: О.Е. Tominа

In out-patient conditions patients were investigated (n=141): of which the core group consisted of patients with hypertension (H) comorbid with peptic ulcer (PU), (n =41), and the comparison group 1 consisted of patients with isolated H (n=58) and comparison group 2 – of patients with isolated PU (n=58). Thefeatures of circadian rhythm of systolic (SBP) and diastolic (DBP) blood pressure, circadian index (CI) in patients with isolated and comorbid H and PU were studied. Get results that when comorbid with PU H – prevailed patho-logic degree of nocturnal SBP reduction (45% of non-dipper and 15% knight-pikker) and normal degree – of DBP (60% dipper). When isolated PU and H with comorbid PU was the smallest value of CI (1,19), which may indicate a negative modifying effect of PU on the H.

82-88

Authors: O.V. Petyunina, N.P. Kopitsa, O.V. Degtyareva

In the absence of ischemic changes on ECG should be assessed biomarkers to exclude myocardial infarc-tion (MI), and further diagnostic testing to exclude ischemia in patients without MI. Although for the diagno-sis of MI is routinely used by a number of biomarkers, only three of them – myoglobin, CPK-MB (CK-MB) and troponin – the most frequently used in cardiology practice. In addition, these markers are also used to identify patients at risk of recurrent cardiac events. Among the many new biomarkers in acute coronary syn-drome, according to the results of individual studies, high expectations on lipoprotein associated phospho-lipase A2 – a marker of local inflammation in the plaques, high-sensitivity troponin, allowing in the first 2:00 to diagnose MI. Perspective may be a new marker of myocyte injury – cardiac protein that binds free fatty acids (H-FABP), matrix metalloproteinases-9, myeloperoxidase. However, despite the diversity of the con-stantly growing number of new biomarkers that reflect the molecular mechanisms of atherogenesis, from its initiation and ending of myocardial necrosis, to date only 3 of them – troponins, BNP and CRP, have found practical application in clinical cardiology, entered the international recommendations as diagnostic and prognostic markers in treating ACS. At the same time, only troponin is the only biomarkers used for diagnosis, prognosis and choice of tactics of treatment of patients with ACS.

97-103

Authors: N.G. Scherban, V.V. Мyasoedov, Е.А. Shevchenko, V.N. Savchenko

On the basis of system analysis and evaluation of our textbook data, published data, as well as regulatory and procedural documents the problem of using of risk assessment techniques to public health under the influence of unfavorable factors of environment in environmental-hygienic studies as well as in environmental and health practice in Ukraine and Russia was disclosed. It was concluded that lack of effective implementation and practical application of this methodology in Ukraine exists. Recommendations were developed to optimize the situation, in particular through the formation of system of personnel training and Ukrainian and regional «Associations of risk assessment to human health».