The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

9-16

Authors: V. O. Bubalo

In this article the main results of the sensitivity to antibiotics on S. Typhimurium, S. strains of Salmonella Enteritidis and rare groups that circulate in Ukraine last 10 years were described. The unifying disc-fusion method determined the sensitivity of Salmonella strains to several antibiotics. Resistance to antibiotics of strains of Salmonella was caused by the lack of effective influence of drugs on salmonellosis. The obtained results revealed antibiotics with a strong antimicrobial action and a narrow focus on strains of Salmonella.

23-27

Authors: T. I. Lyadova, О. V. Volobuyeva, Т. V. Sevastyanova, А. N. Savvo

The article presents the results of the study, during which the efficacy of levofloxacin in the treatment of patients with community-acquired pneumonia was evaluated. It was found that levofloxacin is a highly effective treatment for patients with community-acquired pneumonia.

33-40

Authors: M. I. Shevchuck

Studied indicators of heart rate and arterial pressure variability (HRV, AP) in patients with arterial hypertension (AH) in treatment groups of beta -blocker (BB), inhibitors of angiotensinconverting enzyme (IACE) and their combination classes and duration of the QRS complex ECG ≤ 100 and > 100 ms. 138 patients with AH of the 1-2 degrees (60 men and 78 women) at the age of 57 ± 17 years old were examined. Registration and measurement of QRS complex duration and indices of HRV ECG were done on computer electrocardiograph conducted «Cardiolab+». In groups of thera-py classes of ECG QRS complex duration <100 ms and ≥100 ms were derived. Patients were treated with lisinopril in the average daily dose of 20 mg, bisoprolol - 5 mg. Patients were assessed before, after 2 weeks, 1, 6 and 12 months after of therapy. HRV was evaluated TP, VLF, LF, HF, SAP, DAP in groups of IACE, BB and IACE + BB and classes QRS ECG. The data were processed with the help of Microsoft Excel program. In patients with AH in IACE group the best response of HRV indices ontherapy was indicated in the class of ECG QRS complex duration ≤ 100 ms and in group IACE+ B B− > 100 ms. In patients with AH of ECG QRS complex duration ≤ 100 ms in antihypertensive therapy IACE lizinopril is preferable with ECG QRS complex duration > 100 ms – combination of IACE lizinopril and BB bisoprolol.

46-52

Authors: N. T. Vatutin, М. А. Khrystychenko, E. V. Keting

OBJECTIVE: To evaluate the quality of life (QоL) in patients with anxiety and depressive disorders (ADD) and chronic heart failure (CHF) of ischemic origin. METHODS: The study involved 142 patients (85 men and 57 women, mean age 66,4 ± 10,5 years) with CHF NYHA II-IV functional class. To identify anxiety and depression were used Hospital Anxiety and Depression Scale (HADS), the scales of the Spielberger-Hanin and Beck’s, QоL – Minnesota QоL Questionnaire “Living with Heart Failure» (MLHFQ) and the SF-36 questionnaire. RESULTS: ADD prevalence in patients with CHF of ischemic etiology was 78.1 %, with the largest share in the combination of anxiety and depressive disorders. The deterioration of QoL was observed in all patients with CHF, but the most pronounced decrease in its registered patients with a combination of anxiety and depression. The obtained data was processed using the statistical suite Statistica 6.0 for Windows and presented as M ± σ (mean ± standard deviation). CONCLUSIONS: The presence of ADD leads to a significant decrease in QoL of patients with CHF, the most significant of its deterioration observed in the combination of anxiety and depression. The article presents the results of investigation of gastric mucosal microcirculation with the help of laser-Doppler flowmetry in acute phase of duodenal ulcer during 7 and 14-day eradication therapy. The study enabled to obtain some data on effectiveness of the two therapeutic eradication regimens as well as their im-pact on gastric mucosal microcirculation in the process of ulcer defects healing.

57-60

Authors: M. V. Baeva, A. V. Krotenko, L. A. Martimyanova, E. P. Kamenskaya, S. Alshorman

Prinzmetal Angina (synonyms: vasospastic angina, variant angina) in accordance with the definition of, it is caused by coronary artery spasm which occurs during sleep at night, between midnight and early morning and manifested with ST segment elevation on the ECG. Frequent “attachment” to the attacks of a certain period of the sleep period, gives you the opportunity to use chronomedical approaching the treatment of patients suffering from it, as demonstrated by our observation. On the other hand, for adulthood comorbidity is characteristic, and Prinzmetal is no exception, which we wanted to show, studying the clinical case.

66-70

Authors: E. V. Gavrilyuk, Y. Y. Boeva, I. Anyasi, M. S. Maltseva, D .E. Volkov

Clinical case of persistent atrial flutter in combination with comorbid pathology is presented. Clinical diagnosis, choice of optimal interventional and drug therapy are discussed. Catheter ablation was considered as the optimal method for radical treatment of the atrial flutter. A modification of drug therapy is required according to the condition of the patient after the catheter ablation.

83-88

Authors: N. P. Kopytsya, A. V. Kobets

With increasing numbers of patients with acute coronary syndrome (ACS) it is very important to have reliable biomarkers for early diagnostics and treatment. The role of heart-type fatty acid binding protein (H-FABP) is investigated to confirm patients with ACS and to evaluate the long-term prediction of complications and death. H-FABP allows to define myocardial infarction with changes on ECG and without ST elevation, it helps to differentiate unstable angina. H-FABP sensitivity is higher than troponin, myoglobin and other biomarkers, at the same time H-FABP has a high specificity. Increasing of the H-FABP level is an independent prognostic factor in the long-term prediction in patients with suspected ACS. H-FABP definition, especially in combination with other biomarkers, has the important value, when the diagnosis of ACS is difficult against the background of the atypical clinical picture, the absence of typical ECG changes.

98-110

Authors: I. V. Soldatenko

Etiologic, epidemiologic, pathogenic and clinical description of ankylosing spondylitis are discussed in the lectures. Basic approaches to diagnostics, medical treatment and prophylaxis of disease are represented.