INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

966-999

Authors: Kandimalla. Chaitanya * , Bandlamudi. Yasaswini, Sudhakar R, Minu K George

Tuberculous Meningitis (TBM) is the most dr eaded form of tuberculosis (TB) with Central Nervous system involvement which has very high morbidity and mortality rate. It is noted in 5 to 10% of extra pulmonary TB cases, and accounts for approximately 1% of all Tuberculosis cases. Multi - drug regimen i ncludes Isoniazid, Rifampin, Ethambutol, Pyrazinamide and Streptomycin along with adjunctive treatment with corticosteroids is required in the effective management of Tuberculosis meningitis. Anti - Tuberculosis Therapy induced Hepatotoxicity is the well - kno wn side effect of several drugs which are used for the treatment of TB and it is found to be 2% to 28%. We report a case of ATT induced hepatitis (Isoniazid - Rifampin) along with tuberculosis meningitis complications such as grade II Obstructive Hydrocephal us and hyponatremia and it is successful management with Inj.Mannitol and Inj.Dexamethasone. Key Words: Tuberculous Meningitis, ATT induced Hepatitis, Hydrocephalus, Hyponatremia

984-987

Authors: Indrayani D. Raut * , Dipak S. Gumate, Tushar Chavan, Swati Chavan

Hypertension is a major disor d er that worsens the quality of life. Newer drugs are being introduced in order to treat the the hypertension. A market sur v ey of various antihypertensive drugs was carried out in the region of Islampur. the objective of the study was to find out the most frequently used drug for the antihypertensive treatment. The study revealed that the sympathoytic drugs were most used drugs followed by calcium channel b lockers and AT II receptor antagonists. Keywards: Hypertension, survey, Antihypertensive drugs.

1000-1006

Authors: C. V. S. Raghu Kiran *1 , C. Gopinath 2

The objective of the present study was to develop floating tablets of lafutidine in order to achieve an extended retention in the upper GITwhich may enhance the absorption and improve the bioavailability.The tablets were prepared by gas generation technique using differentratio and concentrations of natural gums like guar gum, gum karaya, hupu gum. Lafutidine a newly developed histamine H2 - receptor antagonist wasretained in the stomach and assist in improving the oral sustaineddelivery of drugs in the gastrointestinal tract. The prepared tablets ofvarious formulations were characterized for a total floating time, buoy ancy lag time, andpercentage drug released. The blend was characterized for determination ofangle of repose, Hausner’s ratio, compressibility, bulk density and tapped density. The floating tablets wereevaluated for determination of weight variation, hardne ss, friability, content uniformity,floating lag time, total floating time, in – vitro drug release study, stability studies. The flowproperties of prepared floating tablets were found to be excellent. Tablets showed satisfactory characteristics with respect to weight, hardness and friability data. The formulation code F10 showed superior results it may be constructive for prolongeddrug release in the stomach to get better the bioavailability and abridged the dose frequency. Optimized floating tablets showed n o significant changes in the physicalappearance, drug content, total buoyancy time, and also in vitro dissolution pattern afterstorage at 40°C/75% relative humidity for 3 months. Key words: Gastro retentive drug delivery system, lafutidine, stability studi es, in - vitro drug release study.

1013-1027

Authors: A. Kumari* 1 , Aniket Singh, S . S. Saurabh 1 , K . S. Rathore 2 , R . Issara ni 1

The present work was carried out with the grail of formulating a gel lified emulsion of lycopene, an anti - oxidative agent. The distinctive feature of topical drug delivery system is the direct accessibility of the skin as a target organ for diagnosis and treatment. Emulgels have emerged as one of the most prevailing drug de livery systems for the delivery of hydrophobic drugs owing to their dual control release system i.e. gel and emulsion. Lycopene, as a natural source of anti - oxidants, has enamoured attention due to its biological and physicochemical properties. It is compl etely insoluble in water, so to overcome this limitation, an emulsion based approach was being used so that even this hydrophobic moiety can enjoy the unique property of gels. Lycopene, an anti - oxidative agent, has been used in the treatment of various oxi dative diseases. This pigment protects the cells against damage from the free radicals formed when body cells burn oxygen for energy. In order to decrease the oxidative reactions with skin i.e. to treat acne vulgaris, lycopene emulgel was developed. This w ork was conducted to develop an emulgel of lycopene using three different gelling agents i.e. Carbopol 934P, HPMC LV - 15 and NaCMC. Oleic acid was used as a penetration enhancer. The gellified emulsions were characterized for their physical appearance, rheo logy, spreadability, drug content and stability. In - vitro release studies were conducted to check the drug release through egg membrane. The formulations were evaluated for their antioxidant activity as well as their acute skin irritation potential. Formul ation F1 was found to have fallen within the stipulated criteria of all the evaluation parameters. Hence, it was concluded that formulation F1, containing carbopol 934P (1% w/w), was the optimized formulation. It exhibited the maximum drug release and anti oxidant activity, in addition to the least skin irritation potential. Keywords: Lycopene, Emulgel, Gelling agents, Anti - oxidant, gellified emulsion.

1038-1047

Authors: P. Sneha * , Prathima Srinivas

A simple, pre cise, accurate, reproducible Stability indicating RP - HPLC method was developed for the determination o f Pregabalin in pharmaceutical dosage forms. After optimization chromatographic separation was achieved by Isocratic mode with a mixture of dipotassium hydrogen phosphate: methanol in the ratio of 60:40% v/v as the mobile phase with AGILENT ZORBAX SB - ODS C18 ( 250 × 4.6 mm I.D) 5 μm column as stationary phase at flow rate of 1 mL/min and detection wavelength of 247 nm. The retention time for Pregabalin found to be 2.00 min respectively. The linearity of this method was found in the concentration range of 50 μg/mL to 150 μg/mL for pregabalin . The correlation coefficient R 2 value is found to be 0.99 for Pregabalin . The LOD and LOQ for pregabalin were found to be 0.53 μg/mL and 1.61 μg/mL respectively. Percentage recovery for pregabalin were found to be 1 00% which indicates that the proposed method is highly accurate. The drug was subjected to acid hydrolysis, base hydrolysis, peroxide, heat and sunlight degradation and the method was found to be specific and stability indicating as no interfering peaks of degradants and excipients were observed. Keywords: Pregabalin , RP - HPLC, Dosage form, Stability indicating.

1057-1064

Authors: S rinivasulu . P*, Vijetha . P , T. N. V . G anesh K umar , D. S uryanarayana R aju, S. V idyadhara

The antidiabetic activity is determined by estimating blood glucose levels and body weights in di abetic rats. Wound healing activity was determined by excision method. There is significant reduction of blood glucose levels from 1 week to 4 weeks in ethanolic extract treated group compared to the control group. The body weights are also increase in eth anolic extract treated group when compared to control group. The ethanolic extract ointment treated group was shown significant wound healing activity in diabetic rats when compared to the control and is almost near to standard group . Here we conclude this combination of ethanolic extract of Ficus bengalensis and Trigonella foenum - graecum was showed significant antidiabetic, weight gain and wound healing activity in alloxan induced diabetic rat model. Key words: Diabetes mellitus, Ficus bengalensis, Trig onella foenum - graecum , Antidiabetic, Ethanolic extract