FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILM OF ATAZANAVIR
Authors: K. Rama Krishna*
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The aim of the preset study was to develop oral fast dissolving films of Atazanavir by solvent casting method.
Low viscosity grades of HPMC such as E3, E6, and E15 were used in the ratio of 1:3, 1:6 and 1:9 as the film
forming polymers. taste masking was done by incorporating suitable sweeteners and flavours. The prepared
films were evaluated for properties like weight variation, folding endurance, thickness, % drug content, invitro
disintegrating time and invitro drug release study. Drug and excipient compatibility was established through
FTIR and DSC study. Form the obtained results, it was concluded that formulations prepared with HPMC E3,
showed good film forming capacity with complete drug release in 10 mins. FTRI and DSC study proved that
there is no drug and polymer interaction.
Keywords: Atazanavir, oral fast dissolving films, HPMC, taste masking, urticaria.